MIR4271

Summary

MIR4271 (microRNA 4271, HGNC:38332) is a microRNA gene on chromosome 3p21.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422952 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38332
Approved symbol	MIR4271
Name	microRNA 4271
Location	3p21.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4271
Ensembl gene	ENSG00000264633
Ensembl biotype	miRNA
OMIM	617176
Entrez	100422952
RNAcentral	URS000075D1DC — ncRNA, 67 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000582451

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000582451 — 1 exons

Exon	Start	End
ENSE00002690286	49274120	49274186

Expression profiles

Bgee: expression breadth broad, 38 present calls, max score 74.42.

Top tissues by expression

38 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
leukocyte	CL:0000738	74.42	gold quality
ascending aorta	UBERON:0001496	68.00	gold quality
putamen	UBERON:0001874	65.95	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	65.66	gold quality
esophagus mucosa	UBERON:0002469	65.55	gold quality
hypothalamus	UBERON:0001898	64.51	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	63.72	gold quality
heart left ventricle	UBERON:0002084	63.63	gold quality
blood	UBERON:0000178	63.53	gold quality
skin of abdomen	UBERON:0001416	62.95	gold quality
tibial artery	UBERON:0007610	62.85	gold quality
omental fat pad	UBERON:0010414	62.78	gold quality
left adrenal gland	UBERON:0001234	62.62	gold quality
esophagus	UBERON:0001043	62.30	gold quality
adenohypophysis	UBERON:0002196	62.15	gold quality
skin of leg	UBERON:0001511	62.01	gold quality
thoracic mammary gland	UBERON:0005200	61.89	gold quality
endocervix	UBERON:0000458	61.81	gold quality
transverse colon	UBERON:0001157	61.81	gold quality
prostate gland	UBERON:0002367	60.08	gold quality
lower esophagus muscularis layer	UBERON:0035833	58.79	gold quality
brain	UBERON:0000955	58.64	gold quality
subcutaneous adipose tissue	UBERON:0002190	57.35	gold quality
left ovary	UBERON:0002119	57.28	gold quality
left uterine tube	UBERON:0001303	57.06	gold quality
nucleus accumbens	UBERON:0001882	55.76	gold quality
right frontal lobe	UBERON:0002810	55.00	gold quality
muscle layer of sigmoid colon	UBERON:0035805	54.97	gold quality
right lobe of thyroid gland	UBERON:0001119	53.54	gold quality
left lobe of thyroid gland	UBERON:0001120	53.46	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• rs4225 in the 3’-UTR of APOC3 might contribute to the risk of coronary heart disease by interfering with miR-4271 binding. (PMID:27624799)
• Report no significant difference in the serum levels of miRNA-4271 between stroke patients and healthy controls. (PMID:28111007)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.