MIR4272

Summary

MIR4272 (microRNA 4272, HGNC:38303) is a microRNA gene on chromosome 3p14.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422941 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38303
Approved symbol	MIR4272
Name	microRNA 4272
Location	3p14.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4272
Ensembl gene	ENSG00000283298
Ensembl biotype	miRNA
Entrez	100422941
RNAcentral	URS000075C7DC — miRNA, 64 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000635924

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000635924 — 1 exons

Exon	Start	End
ENSE00003795128	67225464	67225527

Expression profiles

Bgee: expression breadth broad, 22 present calls, max score 86.35.

Top tissues by expression

22 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	86.35	gold quality
blood	UBERON:0000178	77.99	gold quality
stomach	UBERON:0000945	73.64	gold quality
right frontal lobe	UBERON:0002810	72.28	gold quality
body of stomach	UBERON:0001161	72.27	gold quality
monocyte	CL:0000576	72.11	gold quality
upper lobe of left lung	UBERON:0008952	69.20	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	66.88	gold quality
tibial nerve	UBERON:0001323	66.64	gold quality
vagina	UBERON:0000996	65.17	gold quality
prostate gland	UBERON:0002367	65.03	gold quality
transverse colon	UBERON:0001157	64.81	gold quality
skin of leg	UBERON:0001511	64.21	gold quality
subcutaneous adipose tissue	UBERON:0002190	63.73	gold quality
left lobe of thyroid gland	UBERON:0001120	60.59	gold quality
esophagus mucosa	UBERON:0002469	60.35	gold quality
pituitary gland	UBERON:0000007	57.53	gold quality
colon	UBERON:0001155	56.10	gold quality
muscle layer of sigmoid colon	UBERON:0035805	56.00	gold quality
liver	UBERON:0002107	55.66	gold quality
left testis	UBERON:0004533	42.82	gold quality
right testis	UBERON:0004534	40.91	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.66

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.