MIR4274

Summary

MIR4274 (microRNA 4274, HGNC:38194) is a microRNA gene on chromosome 4p16.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422826 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38194
Approved symbol	MIR4274
Name	microRNA 4274
Location	4p16.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4274
Ensembl gene	ENSG00000266690
Ensembl biotype	miRNA
Entrez	100422826
RNAcentral	URS000075A146 — miRNA, 91 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000579577

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000579577 — 1 exons

Exon	Start	End
ENSE00002697372	7460028	7460118

Expression profiles

Bgee: expression breadth broad, 31 present calls, max score 77.68.

Top tissues by expression

31 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
liver	UBERON:0002107	77.68	gold quality
body of stomach	UBERON:0001161	75.93	gold quality
monocyte	CL:0000576	75.67	gold quality
adult mammalian kidney	UBERON:0000082	74.05	gold quality
anterior cingulate cortex	UBERON:0009835	72.11	gold quality
stomach	UBERON:0000945	71.11	gold quality
Brodmann (1909) area 9	UBERON:0013540	70.22	gold quality
omental fat pad	UBERON:0010414	69.90	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	68.56	gold quality
substantia nigra	UBERON:0002038	66.70	gold quality
thyroid gland	UBERON:0002046	65.83	gold quality
right frontal lobe	UBERON:0002810	65.46	gold quality
skin of leg	UBERON:0001511	64.92	gold quality
lower esophagus muscularis layer	UBERON:0035833	64.29	gold quality
esophagus mucosa	UBERON:0002469	63.52	gold quality
hypothalamus	UBERON:0001898	63.08	gold quality
skin of abdomen	UBERON:0001416	62.76	gold quality
tibial nerve	UBERON:0001323	62.13	gold quality
minor salivary gland	UBERON:0001830	61.81	gold quality
left ovary	UBERON:0002119	60.80	gold quality
nucleus accumbens	UBERON:0001882	60.47	gold quality
Ammon’s horn	UBERON:0001954	60.36	gold quality
putamen	UBERON:0001874	60.34	gold quality
caudate nucleus	UBERON:0001873	59.81	gold quality
small intestine Peyer’s patch	UBERON:0003454	59.28	gold quality
vagina	UBERON:0000996	58.11	gold quality
pituitary gland	UBERON:0000007	54.28	gold quality
colon	UBERON:0001155	48.32	gold quality
testis	UBERON:0000473	47.09	gold quality
right testis	UBERON:0004534	46.11	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.32

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• This study demonstrated that the levels of CSF hsa-miR-4274 can differentiate parkinsonian spectrum from patients with Normal Pressure Hydrocephalus , Alzheimer disease, and normal control. (PMID:27911315)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.