MIR4275

Summary

MIR4275 (microRNA 4275, HGNC:38293) is a microRNA gene on chromosome 4p15.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422937 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38293
Approved symbol	MIR4275
Name	microRNA 4275
Location	4p15.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4275
Ensembl gene	ENSG00000283275
Ensembl biotype	miRNA
Entrez	100422937
RNAcentral	URS000075A242 — ncRNA, 87 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000636486

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000636486 — 1 exons

Exon	Start	End
ENSE00003794017	28819582	28819668

Expression profiles

Bgee: expression breadth broad, 17 present calls, max score 83.30.

Top tissues by expression

17 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
myometrium	UBERON:0001296	83.30	gold quality
lung	UBERON:0002048	80.62	gold quality
monocyte	CL:0000576	80.20	gold quality
stomach	UBERON:0000945	78.46	gold quality
endometrium	UBERON:0001295	78.39	gold quality
heart	UBERON:0000948	72.16	gold quality
blood	UBERON:0000178	69.88	gold quality
Brodmann (1909) area 9	UBERON:0013540	69.40	gold quality
intestine	UBERON:0000160	67.46	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	63.01	gold quality
left ovary	UBERON:0002119	62.78	gold quality
omental fat pad	UBERON:0010414	62.67	gold quality
colon	UBERON:0001155	61.73	gold quality
right hemisphere of cerebellum	UBERON:0014890	58.61	gold quality
corpus callosum	UBERON:0002336	56.06	gold quality
left testis	UBERON:0004533	48.93	gold quality
testis	UBERON:0000473	48.47	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.99

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.