MIR4276

Summary

MIR4276 (microRNA 4276, HGNC:38232) is a microRNA gene on chromosome 4q34.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100423042 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38232
Approved symbol	MIR4276
Name	microRNA 4276
Location	4q34.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4276
Ensembl gene	ENSG00000265846
Ensembl biotype	miRNA
OMIM	616274
Entrez	100423042
RNAcentral	URS000075DD5E — ncRNA, 70 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000584832

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000584832 — 1 exons

Exon	Start	End
ENSE00002701336	174423795	174423864

Expression profiles

Bgee: expression breadth tissue_specific, 7 present calls, max score 74.23.

Top tissues by expression

7 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	74.23	gold quality
muscle layer of sigmoid colon	UBERON:0035805	65.15	gold quality
caudate nucleus	UBERON:0001873	62.48	gold quality
right frontal lobe	UBERON:0002810	60.32	gold quality
Brodmann (1909) area 9	UBERON:0013540	60.25	gold quality
substantia nigra	UBERON:0002038	56.92	gold quality
left testis	UBERON:0004533	41.47	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.14

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Within the first 3h of infection with influenza virus, significant down-regulation of hsa-miRNA-4276 is followed by a 2-fold increase in cytochrome c oxidase VIc mRNA was found to occur in human alveolar and bronchial epithelial cells. (PMID:25203353)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.