MIR4277

Summary

MIR4277 (microRNA 4277, HGNC:38367) is a microRNA gene on chromosome 5p15.33.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422966 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38367
Approved symbol	MIR4277
Name	microRNA 4277
Location	5p15.33
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4277
Ensembl gene	ENSG00000263746
Ensembl biotype	miRNA
Entrez	100422966
RNAcentral	URS000075D469 — miRNA, 84 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000578298

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000578298 — 1 exons

Exon	Start	End
ENSE00002721094	1708785	1708868

Expression profiles

Bgee: expression breadth broad, 33 present calls, max score 75.32.

Top tissues by expression

33 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	75.32	gold quality
right atrium auricular region	UBERON:0006631	70.98	gold quality
left adrenal gland cortex	UBERON:0035825	70.00	gold quality
lung	UBERON:0002048	69.98	gold quality
left adrenal gland	UBERON:0001234	68.29	gold quality
colon	UBERON:0001155	67.88	gold quality
subcutaneous adipose tissue	UBERON:0002190	66.79	gold quality
gall bladder	UBERON:0002110	66.37	gold quality
minor salivary gland	UBERON:0001830	66.19	gold quality
adrenal gland	UBERON:0002369	66.19	gold quality
fallopian tube	UBERON:0003889	66.17	gold quality
esophagus	UBERON:0001043	66.01	gold quality
esophagus mucosa	UBERON:0002469	65.91	gold quality
right adrenal gland	UBERON:0001233	65.53	gold quality
body of stomach	UBERON:0001161	65.07	gold quality
right adrenal gland cortex	UBERON:0035827	64.85	gold quality
skin of leg	UBERON:0001511	64.76	gold quality
skin of abdomen	UBERON:0001416	64.43	gold quality
transverse colon	UBERON:0001157	62.72	gold quality
vagina	UBERON:0000996	62.66	gold quality
anterior cingulate cortex	UBERON:0009835	61.36	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	61.26	gold quality
small intestine Peyer’s patch	UBERON:0003454	60.49	gold quality
prostate gland	UBERON:0002367	59.92	gold quality
left lobe of thyroid gland	UBERON:0001120	58.96	gold quality
thyroid gland	UBERON:0002046	58.94	gold quality
right ovary	UBERON:0002118	58.15	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	56.46	gold quality
nucleus accumbens	UBERON:0001882	56.36	gold quality
caudate nucleus	UBERON:0001873	54.52	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.18

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.