MIR4278

Summary

MIR4278 (microRNA 4278, HGNC:38243) is a microRNA gene on chromosome 5p15.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422999 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38243
Approved symbol	MIR4278
Name	microRNA 4278
Location	5p15.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4278
Ensembl gene	ENSG00000283420
Ensembl biotype	miRNA
Entrez	100422999
RNAcentral	URS000075E415 — miRNA, 69 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000636094

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000636094 — 1 exons

Exon	Start	End
ENSE00003794068	6827853	6827921

Expression profiles

Bgee: expression breadth broad, 48 present calls, max score 75.60.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0482 / max 13.0498, expressed in 13 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
60861	0.0482	13

Top tissues by expression

48 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	75.60	gold quality
calcaneal tendon	UBERON:0003701	74.99	gold quality
monocyte	CL:0000576	73.96	gold quality
gastrocnemius	UBERON:0001388	73.63	gold quality
heart left ventricle	UBERON:0002084	73.07	gold quality
islet of Langerhans	UBERON:0000006	71.32	gold quality
tibial artery	UBERON:0007610	71.20	gold quality
lower esophagus muscularis layer	UBERON:0035833	70.76	gold quality
skin of abdomen	UBERON:0001416	68.46	gold quality
left coronary artery	UBERON:0001626	68.07	gold quality
right atrium auricular region	UBERON:0006631	67.74	gold quality
hypothalamus	UBERON:0001898	67.72	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.65	gold quality
left adrenal gland	UBERON:0001234	67.60	gold quality
Ammon’s horn	UBERON:0001954	67.40	gold quality
esophagus mucosa	UBERON:0002469	67.35	gold quality
muscle layer of sigmoid colon	UBERON:0035805	67.02	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	66.51	gold quality
thyroid gland	UBERON:0002046	66.25	gold quality
Brodmann (1909) area 9	UBERON:0013540	66.16	gold quality
nucleus accumbens	UBERON:0001882	65.88	gold quality
transverse colon	UBERON:0001157	65.84	gold quality
putamen	UBERON:0001874	65.30	gold quality
cerebral cortex	UBERON:0000956	65.29	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	65.17	gold quality
right frontal lobe	UBERON:0002810	64.82	gold quality
ascending aorta	UBERON:0001496	64.75	gold quality
skin of leg	UBERON:0001511	64.60	gold quality
frontal cortex	UBERON:0001870	64.60	gold quality
mucosa of stomach	UBERON:0001199	64.13	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.