MIR4279

Summary

MIR4279 (microRNA 4279, HGNC:38195) is a microRNA gene on chromosome 5p13.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422874 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38195
Approved symbol	MIR4279
Name	microRNA 4279
Location	5p13.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4279
Ensembl gene	ENSG00000266243
Ensembl biotype	miRNA
Entrez	100422874
RNAcentral	URS000075B6EF — ncRNA, 58 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000582091

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000582091 — 1 exons

Exon	Start	End
ENSE00002703272	31936102	31936159

Expression profiles

Bgee: expression breadth broad, 29 present calls, max score 94.11.

Top tissues by expression

29 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	94.11	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	82.92	gold quality
monocyte	CL:0000576	80.51	gold quality
tibial nerve	UBERON:0001323	77.60	gold quality
heart	UBERON:0000948	72.13	gold quality
adult mammalian kidney	UBERON:0000082	70.48	gold quality
putamen	UBERON:0001874	69.94	gold quality
ascending aorta	UBERON:0001496	69.89	gold quality
heart left ventricle	UBERON:0002084	69.80	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	69.08	gold quality
vagina	UBERON:0000996	67.71	gold quality
esophagus mucosa	UBERON:0002469	66.74	gold quality
Brodmann (1909) area 9	UBERON:0013540	66.55	gold quality
ovary	UBERON:0000992	66.31	gold quality
skin of abdomen	UBERON:0001416	66.07	gold quality
skin of leg	UBERON:0001511	65.95	gold quality
colon	UBERON:0001155	65.74	gold quality
subcutaneous adipose tissue	UBERON:0002190	65.66	gold quality
substantia nigra	UBERON:0002038	65.44	gold quality
lower esophagus muscularis layer	UBERON:0035833	65.05	gold quality
omental fat pad	UBERON:0010414	64.45	gold quality
transverse colon	UBERON:0001157	64.33	gold quality
left ovary	UBERON:0002119	64.14	gold quality
left uterine tube	UBERON:0001303	64.02	gold quality
thoracic mammary gland	UBERON:0005200	63.74	gold quality
nucleus accumbens	UBERON:0001882	63.23	gold quality
caudate nucleus	UBERON:0001873	62.50	gold quality
corpus callosum	UBERON:0002336	50.46	silver quality
left testis	UBERON:0004533	49.02	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.33

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.