MIR4280

Summary

MIR4280 (microRNA 4280, HGNC:38334) is a microRNA gene on chromosome 5q14.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422887 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38334
Approved symbol	MIR4280
Name	microRNA 4280
Location	5q14.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4280
Ensembl gene	ENSG00000265919
Ensembl biotype	miRNA
Entrez	100422887
RNAcentral	URS000075A68B — ncRNA, 76 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000582178

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000582178 — 1 exons

Exon	Start	End
ENSE00002686936	87114879	87114954

Expression profiles

Bgee: expression breadth broad, 24 present calls, max score 79.27.

Top tissues by expression

24 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	79.27	gold quality
adrenal tissue	UBERON:0018303	78.34	gold quality
kidney	UBERON:0002113	74.41	gold quality
body of pancreas	UBERON:0001150	71.15	gold quality
heart left ventricle	UBERON:0002084	70.69	gold quality
lymph node	UBERON:0000029	70.61	gold quality
endometrium	UBERON:0001295	69.98	gold quality
left adrenal gland cortex	UBERON:0035825	69.89	gold quality
left adrenal gland	UBERON:0001234	67.42	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	66.34	gold quality
corpus callosum	UBERON:0002336	65.87	gold quality
substantia nigra	UBERON:0002038	64.45	gold quality
omental fat pad	UBERON:0010414	64.28	gold quality
Ammon’s horn	UBERON:0001954	64.13	gold quality
putamen	UBERON:0001874	63.82	gold quality
right frontal lobe	UBERON:0002810	63.81	gold quality
transverse colon	UBERON:0001157	63.02	gold quality
right lobe of thyroid gland	UBERON:0001119	61.84	gold quality
left lobe of thyroid gland	UBERON:0001120	61.64	gold quality
cerebellar hemisphere	UBERON:0002245	60.07	gold quality
Brodmann (1909) area 9	UBERON:0013540	59.60	gold quality
thyroid gland	UBERON:0002046	59.48	gold quality
caudate nucleus	UBERON:0001873	59.00	gold quality
left testis	UBERON:0004533	39.10	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.99

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.