MIR4281

Summary

MIR4281 (microRNA 4281, HGNC:38357) is a microRNA gene on chromosome 5q35.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422962 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38357
Approved symbol	MIR4281
Name	microRNA 4281
Location	5q35.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4281
Ensembl gene	ENSG00000266329
Ensembl biotype	miRNA
Entrez	100422962
RNAcentral	URS000075E5A1 — miRNA, 62 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000580852

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000580852 — 1 exons

Exon	Start	End
ENSE00002707936	176629439	176629500

Expression profiles

Bgee: expression breadth broad, 17 present calls, max score 69.33.

Top tissues by expression

17 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
body of pancreas	UBERON:0001150	69.33	gold quality
right frontal lobe	UBERON:0002810	68.08	gold quality
tibial artery	UBERON:0007610	67.60	gold quality
right adrenal gland cortex	UBERON:0035827	67.13	gold quality
Brodmann (1909) area 9	UBERON:0013540	66.54	gold quality
Ammon’s horn	UBERON:0001954	66.25	gold quality
anterior cingulate cortex	UBERON:0009835	65.97	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	65.26	gold quality
skin of leg	UBERON:0001511	65.01	gold quality
brain	UBERON:0000955	64.41	gold quality
cerebellar hemisphere	UBERON:0002245	63.65	gold quality
caudate nucleus	UBERON:0001873	63.23	gold quality
right hemisphere of cerebellum	UBERON:0014890	63.19	gold quality
hypothalamus	UBERON:0001898	62.16	gold quality
adenohypophysis	UBERON:0002196	60.85	gold quality
nucleus accumbens	UBERON:0001882	60.27	gold quality
pituitary gland	UBERON:0000007	59.88	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.06

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• IL-2/STAT5 signal transduction upregulates FOXP3 expression not only through the classical pathway, but also by enhancing the expression of the miR-4281 precursor gene and, correspondingly, miR-4281. (PMID:29282311)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.