MIR4282

Summary

MIR4282 (microRNA 4282, HGNC:38189) is a microRNA gene on chromosome 6q13.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100423005 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38189
Approved symbol	MIR4282
Name	microRNA 4282
Location	6q13
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4282
Ensembl gene	ENSG00000266180
Ensembl biotype	miRNA
Entrez	100423005
RNAcentral	URS000075C69B — ncRNA, 67 nt, 14 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000583613

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000583613 — 1 exons

Exon	Start	End
ENSE00002723073	72967687	72967753

Expression profiles

Bgee: expression breadth broad, 26 present calls, max score 80.62.

Top tissues by expression

26 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
kidney	UBERON:0002113	80.62	gold quality
heart	UBERON:0000948	80.11	gold quality
blood	UBERON:0000178	78.54	gold quality
intestine	UBERON:0000160	78.29	gold quality
bone marrow	UBERON:0002371	77.01	gold quality
stomach	UBERON:0000945	76.12	gold quality
lung	UBERON:0002048	75.98	gold quality
body of stomach	UBERON:0001161	74.71	gold quality
endometrium	UBERON:0001295	70.39	gold quality
Ammon’s horn	UBERON:0001954	67.61	gold quality
caudate nucleus	UBERON:0001873	67.07	gold quality
anterior cingulate cortex	UBERON:0009835	66.82	gold quality
Brodmann (1909) area 9	UBERON:0013540	65.21	gold quality
spleen	UBERON:0002106	64.68	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	63.82	gold quality
ascending aorta	UBERON:0001496	62.74	gold quality
frontal cortex	UBERON:0001870	62.16	gold quality
urinary bladder	UBERON:0001255	61.65	gold quality
right frontal lobe	UBERON:0002810	60.81	gold quality
left lobe of thyroid gland	UBERON:0001120	60.78	gold quality
right lobe of thyroid gland	UBERON:0001119	60.70	gold quality
thyroid gland	UBERON:0002046	60.00	gold quality
small intestine Peyer’s patch	UBERON:0003454	58.92	gold quality
tibial artery	UBERON:0007610	57.51	gold quality
corpus callosum	UBERON:0002336	55.59	gold quality
left testis	UBERON:0004533	44.06	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• miR-4282 is a tumor suppressor in colorectal carcinoma cells and exerted its inhibitory effect on the tumor cells through targeting Sema3E by inhibiting Sema3E translation or enhancing Sema3E mRNA degradation. (PMID:27120047)
• miR-4282 was down-regulated in human breast cancer (BC) tissues, particularly in invasive and metastatic tumors. Expression of miR-4282 was related to the occurrence of metastasis and the clinical grade of BC. The results of bioinformatics analysis combined with qRT-PCR and Western blot demonstrated that MYC might be the target gene of miR-4282 in BC. (PMID:30575917)
• MiR-4282 inhibits tumor progression through down-regulation of ZBTB2 by targeting LIN28B in oral squamous cell carcinoma. (PMID:31970774)
• MiR-4282 is a tumor-suppressor gene for preventing metastasis of epithelial ovarian cancer by negatively regulating MIER1. (PMID:34859847)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.