MIR4284

Summary

MIR4284 (microRNA 4284, HGNC:38322) is a microRNA gene on chromosome 7q11.23.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422948 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38322
Approved symbol	MIR4284
Name	microRNA 4284
Location	7q11.23
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4284
Ensembl gene	ENSG00000265724
Ensembl biotype	miRNA
Entrez	100422948
RNAcentral	URS000075D09B — ncRNA, 81 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000578924

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000578924 — 1 exons

Exon	Start	End
ENSE00002694531	73711317	73711397

Expression profiles

Bgee: expression breadth broad, 78 present calls, max score 86.62.

Top tissues by expression

78 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skeletal muscle tissue	UBERON:0001134	86.62	gold quality
lymph node	UBERON:0000029	79.09	gold quality
bone marrow	UBERON:0002371	78.06	gold quality
adrenal tissue	UBERON:0018303	77.80	gold quality
kidney	UBERON:0002113	75.09	gold quality
muscle of leg	UBERON:0001383	74.29	gold quality
monocyte	CL:0000576	73.47	gold quality
blood	UBERON:0000178	73.42	gold quality
islet of Langerhans	UBERON:0000006	73.37	gold quality
gastrocnemius	UBERON:0001388	73.01	gold quality
endometrium	UBERON:0001295	72.46	gold quality
left uterine tube	UBERON:0001303	72.39	gold quality
left coronary artery	UBERON:0001626	70.23	gold quality
heart left ventricle	UBERON:0002084	69.61	gold quality
body of pancreas	UBERON:0001150	68.24	gold quality
heart	UBERON:0000948	68.13	gold quality
tibial artery	UBERON:0007610	68.10	gold quality
Ammon’s horn	UBERON:0001954	67.91	gold quality
granulocyte	CL:0000094	67.83	gold quality
thoracic aorta	UBERON:0001515	67.73	gold quality
ascending aorta	UBERON:0001496	67.58	gold quality
myometrium	UBERON:0001296	67.48	gold quality
putamen	UBERON:0001874	67.26	gold quality
amygdala	UBERON:0001876	67.20	gold quality
liver	UBERON:0002107	66.99	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.70	gold quality
body of stomach	UBERON:0001161	66.31	gold quality
fundus of stomach	UBERON:0001160	66.29	gold quality
muscle layer of sigmoid colon	UBERON:0035805	66.15	gold quality
left adrenal gland	UBERON:0001234	66.11	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.77

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 7)

• Low miR-4284 expression is associated with pediatric ulcerative colitis. (PMID:25738378)
• The level of miR-4284 was significantly increased in Arteriosclerosis Obliterans. (PMID:26370316)
• data demonstrated that miR4284 could promote tumor cell growth, migration and invasion by directly targeting TET1 in gastric cancer, which may provide a potential therapeutic target for gastric cancer treatment. (PMID:29512746)
• Mesenchymal stem cells from ankylosing spondylitis (AS) patients exhibit a stronger capacity to inhibit osteoclastogenesis than mesenchymal stem cells from healthy donors through the miR-4284/CXCL5 axis, which provide a new perspective on the mechanism of pathologic osteogenesis in AS. (PMID:30804325)
• MiR-4282 contributes to inhibit pancreatic cancer metastasis by negatively interacting with ABCB5. (PMID:33090395)
• Long non-coding RNAs PGM5-AS1 upregulates Decorin (DCN) to inhibit cervical cancer progression by sponging miR-4284. (PMID:35420507)
• MiR-4284 inhibits sensitivity to paclitaxel in human ovarian carcinoma SKOV3ip1 and HeyA8 cells by targeting DMC1. (PMID:35946537)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.