MIR4285

Summary

MIR4285 (microRNA 4285, HGNC:38337) is a microRNA gene on chromosome 7q22.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422858 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38337
Approved symbol	MIR4285
Name	microRNA 4285
Location	7q22.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4285
Ensembl gene	ENSG00000264675
Ensembl biotype	miRNA
Entrez	100422858
RNAcentral	URS00007E3A2D — miRNA, 85 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000581001

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000581001 — 1 exons

Exon	Start	End
ENSE00002700533	102293103	102293187

Expression profiles

Bgee: expression breadth broad, 66 present calls, max score 76.25.

Top tissues by expression

66 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	76.25	gold quality
bone marrow	UBERON:0002371	74.32	gold quality
monocyte	CL:0000576	74.07	gold quality
gastrocnemius	UBERON:0001388	73.24	gold quality
granulocyte	CL:0000094	68.61	gold quality
right lobe of liver	UBERON:0001114	67.98	gold quality
body of pancreas	UBERON:0001150	67.97	gold quality
stomach	UBERON:0000945	67.83	gold quality
tibial artery	UBERON:0007610	67.67	gold quality
ascending aorta	UBERON:0001496	66.98	gold quality
thoracic aorta	UBERON:0001515	66.87	gold quality
tonsil	UBERON:0002372	66.81	gold quality
endometrium	UBERON:0001295	66.72	gold quality
body of stomach	UBERON:0001161	66.70	gold quality
transverse colon	UBERON:0001157	66.59	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.57	gold quality
right lobe of thyroid gland	UBERON:0001119	66.43	gold quality
heart left ventricle	UBERON:0002084	66.35	gold quality
heart	UBERON:0000948	65.92	gold quality
descending thoracic aorta	UBERON:0002345	65.91	gold quality
right atrium auricular region	UBERON:0006631	65.90	gold quality
esophagus mucosa	UBERON:0002469	65.84	gold quality
body of uterus	UBERON:0009853	65.42	gold quality
right adrenal gland	UBERON:0001233	65.12	gold quality
colon	UBERON:0001155	65.04	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	65.00	gold quality
subcutaneous adipose tissue	UBERON:0002190	64.83	gold quality
adipose tissue	UBERON:0001013	64.76	gold quality
right hemisphere of cerebellum	UBERON:0014890	64.73	gold quality
Ammon’s horn	UBERON:0001954	64.72	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.17

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.