MIR4286

Summary

MIR4286 (microRNA 4286, HGNC:38186) is a microRNA gene on chromosome 8p23.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422982 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38186
Approved symbol	MIR4286
Name	microRNA 4286
Location	8p23.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4286
Ensembl gene	ENSG00000263762
Ensembl biotype	miRNA
Entrez	100422982
RNAcentral	URS000075E8CE — ncRNA, 93 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000580651

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000580651 — 1 exons

Exon	Start	End
ENSE00002724842	10666978	10667070

Expression profiles

Bgee: expression breadth broad, 60 present calls, max score 83.16.

Top tissues by expression

60 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	83.16	gold quality
tibial artery	UBERON:0007610	81.01	gold quality
adrenal tissue	UBERON:0018303	80.92	gold quality
monocyte	CL:0000576	78.08	gold quality
Brodmann (1909) area 9	UBERON:0013540	76.79	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	75.60	gold quality
gastrocnemius	UBERON:0001388	75.43	gold quality
islet of Langerhans	UBERON:0000006	74.87	gold quality
body of pancreas	UBERON:0001150	74.63	gold quality
left adrenal gland	UBERON:0001234	73.00	gold quality
right adrenal gland	UBERON:0001233	72.58	gold quality
ascending aorta	UBERON:0001496	72.11	gold quality
endometrium	UBERON:0001295	71.60	gold quality
stomach	UBERON:0000945	70.40	gold quality
right atrium auricular region	UBERON:0006631	70.31	gold quality
minor salivary gland	UBERON:0001830	69.53	gold quality
intestine	UBERON:0000160	69.15	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	68.12	gold quality
ectocervix	UBERON:0012249	67.38	gold quality
caudate nucleus	UBERON:0001873	67.28	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.01	gold quality
vagina	UBERON:0000996	66.94	gold quality
substantia nigra	UBERON:0002038	66.87	gold quality
esophagus mucosa	UBERON:0002469	66.75	gold quality
transverse colon	UBERON:0001157	66.54	gold quality
subcutaneous adipose tissue	UBERON:0002190	66.05	gold quality
anterior cingulate cortex	UBERON:0009835	65.98	gold quality
skin of leg	UBERON:0001511	65.78	gold quality
omental fat pad	UBERON:0010414	65.78	gold quality
left coronary artery	UBERON:0001626	65.55	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.16

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 9)

• High miR-4286 expression is associated with Melanoma. (PMID:28005927)
• Our findings reveal that highly expression of miR-4286 may promote the development of esophageal carcinoma by targeting INPP4A to evoke the JAK2/STAT3 pathway activation (PMID:29880087)
• our findings elucidate that miR-4286 promotes the tumorigenesis of NSCLC by interacting with PTEN. This miR-4286-mediated upregulation of PTEN might lead to new therapeutic strategies for NSCLC. (PMID:31074594)
• Overexpression of miR-4286 is an unfavorable prognostic marker in individuals with non-small cell lung cancer. (PMID:31111550)
• miR-4286 promotes prostate cancer progression by targeting the expression of SALL1. (PMID:31693770)
• miR-4286 is Involved in Connections Between IGF-1 and TGF-beta Signaling for the Mesenchymal Transition and Invasion by Glioblastomas. (PMID:33025417)
• NF-kappaB/miR-18a-3p and miR-4286/BZRAP1 axis may mediate carcinogenesis in Helicobacter pylori-Associated gastric cancer. (PMID:33113427)
• Prospective Study on Plasma MicroRNA-4286 and Incident Acute Coronary Syndrome. (PMID:33719498)
• miR-4286 functions in osteogenesis and angiogenesis via targeting histone deacetylase 3 and alleviates alcohol-induced bone loss in mice. (PMID:33973278)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.