MIR4287

Summary

MIR4287 (microRNA 4287, HGNC:38208) is a microRNA gene on chromosome 8p21.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422828 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38208
Approved symbol	MIR4287
Name	microRNA 4287
Location	8p21.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4287
Ensembl gene	ENSG00000265847
Ensembl biotype	miRNA
Entrez	100422828
RNAcentral	URS000075A29B — miRNA, 78 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000579398

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000579398 — 1 exons

Exon	Start	End
ENSE00002728924	27886039	27886116

Expression profiles

Bgee: expression breadth broad, 49 present calls, max score 85.89.

Top tissues by expression

49 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	85.89	gold quality
adrenal tissue	UBERON:0018303	77.36	gold quality
urinary bladder	UBERON:0001255	74.68	gold quality
gastrocnemius	UBERON:0001388	73.97	gold quality
sural nerve	UBERON:0015488	72.64	gold quality
blood	UBERON:0000178	72.39	gold quality
body of pancreas	UBERON:0001150	72.19	gold quality
endometrium	UBERON:0001295	71.90	gold quality
heart left ventricle	UBERON:0002084	71.67	gold quality
myometrium	UBERON:0001296	71.20	gold quality
heart	UBERON:0000948	69.85	gold quality
saliva-secreting gland	UBERON:0001044	68.99	gold quality
right atrium auricular region	UBERON:0006631	68.87	gold quality
stomach	UBERON:0000945	68.40	gold quality
tibial artery	UBERON:0007610	67.74	gold quality
left adrenal gland	UBERON:0001234	67.24	gold quality
body of stomach	UBERON:0001161	66.53	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	66.30	gold quality
right frontal lobe	UBERON:0002810	66.13	gold quality
left coronary artery	UBERON:0001626	65.87	gold quality
muscle layer of sigmoid colon	UBERON:0035805	65.79	gold quality
subcutaneous adipose tissue	UBERON:0002190	65.46	gold quality
esophagus mucosa	UBERON:0002469	65.34	gold quality
lower esophagus muscularis layer	UBERON:0035833	65.16	gold quality
right adrenal gland	UBERON:0001233	64.84	gold quality
transverse colon	UBERON:0001157	64.62	gold quality
colon	UBERON:0001155	64.54	gold quality
ascending aorta	UBERON:0001496	64.07	gold quality
left ovary	UBERON:0002119	63.86	gold quality
right adrenal gland cortex	UBERON:0035827	63.85	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.25

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.