MIR4288

Summary

MIR4288 (microRNA 4288, HGNC:38203) is a microRNA gene on chromosome 8p21.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422903 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38203
Approved symbol	MIR4288
Name	microRNA 4288
Location	8p21.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4288
Ensembl gene	ENSG00000265251
Ensembl biotype	miRNA
Entrez	100422903
RNAcentral	URS000075C449 — miRNA, 67 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000582598

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000582598 — 1 exons

Exon	Start	End
ENSE00002720412	28505116	28505182

Expression profiles

Bgee: expression breadth broad, 40 present calls, max score 85.84.

Top tissues by expression

40 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
kidney	UBERON:0002113	85.84	gold quality
lung	UBERON:0002048	80.46	gold quality
heart	UBERON:0000948	78.87	gold quality
blood	UBERON:0000178	78.43	gold quality
adrenal tissue	UBERON:0018303	77.96	gold quality
stomach	UBERON:0000945	76.39	gold quality
monocyte	CL:0000576	74.30	gold quality
endometrium	UBERON:0001295	74.24	gold quality
adenohypophysis	UBERON:0002196	73.66	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	72.60	gold quality
intestine	UBERON:0000160	70.71	gold quality
body of stomach	UBERON:0001161	69.86	gold quality
liver	UBERON:0002107	69.48	gold quality
tibial artery	UBERON:0007610	68.98	gold quality
body of pancreas	UBERON:0001150	68.80	gold quality
heart left ventricle	UBERON:0002084	68.60	gold quality
ascending aorta	UBERON:0001496	66.83	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.65	gold quality
cerebellar hemisphere	UBERON:0002245	66.62	gold quality
skin of abdomen	UBERON:0001416	66.41	gold quality
right hemisphere of cerebellum	UBERON:0014890	65.94	gold quality
subcutaneous adipose tissue	UBERON:0002190	65.91	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	65.51	gold quality
left lobe of thyroid gland	UBERON:0001120	65.29	gold quality
colon	UBERON:0001155	63.84	gold quality
omental fat pad	UBERON:0010414	63.39	gold quality
right frontal lobe	UBERON:0002810	63.27	gold quality
nucleus accumbens	UBERON:0001882	63.21	gold quality
ectocervix	UBERON:0012249	62.91	gold quality
skin of leg	UBERON:0001511	62.55	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.33

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Low miR4288 expression is associated with prostate cancer progression. (PMID:30874288)
• the present study demonstrated that LINC00978 promoted bladder cancer (BCa) progression by sponging miR4288, suggesting that LINC00978 may represent a potential therapeutic target for bladder cancer (BCa) treatment. (PMID:31257499)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.