MIR4289

Summary

MIR4289 (microRNA 4289, HGNC:38278) is a microRNA gene on chromosome 9q22.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100423015 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38278
Approved symbol	MIR4289
Name	microRNA 4289
Location	9q22.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4289
Ensembl gene	ENSG00000265873
Ensembl biotype	miRNA
Entrez	100423015
RNAcentral	URS000075B705 — ncRNA, 70 nt, 5 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000581736

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000581736 — 1 exons

Exon	Start	End
ENSE00002714576	88745836	88745905

Expression profiles

Bgee: expression breadth tissue_specific, 5 present calls, max score 65.79.

Top tissues by expression

5 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
endometrium	UBERON:0001295	65.79	gold quality
right frontal lobe	UBERON:0002810	60.65	gold quality
prostate gland	UBERON:0002367	57.16	gold quality
pituitary gland	UBERON:0000007	55.98	gold quality
left testis	UBERON:0004533	43.54	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.52

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.