MIR429

Summary

MIR429 (microRNA 429, HGNC:13784) is a microRNA gene on chromosome 1p36.33.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 554210 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:13784
Approved symbol	MIR429
Name	microRNA 429
Location	1p36.33
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-429
Ensembl gene	ENSG00000198976
Ensembl biotype	miRNA
OMIM	612094
Entrez	554210
RNAcentral	URS000075B715 — miRNA, 83 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000362106

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000362106 — 1 exons

Exon	Start	End
ENSE00001436869	1169005	1169087

Expression profiles

Bgee: expression breadth broad, 90 present calls, max score 97.78.

Top tissues by expression

90 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
fundus of stomach	UBERON:0001160	97.78	gold quality
mucosa of transverse colon	UBERON:0004991	97.00	gold quality
body of stomach	UBERON:0001161	96.39	gold quality
right uterine tube	UBERON:0001302	95.71	gold quality
pituitary gland	UBERON:0000007	95.55	gold quality
body of pancreas	UBERON:0001150	95.44	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	95.36	gold quality
endocervix	UBERON:0000458	95.06	gold quality
transverse colon	UBERON:0001157	94.98	gold quality
stomach	UBERON:0000945	94.87	gold quality
metanephros cortex	UBERON:0010533	94.87	gold quality
adenohypophysis	UBERON:0002196	94.72	gold quality
duodenum	UBERON:0002114	93.81	gold quality
small intestine	UBERON:0002108	93.69	gold quality
small intestine Peyer’s patch	UBERON:0003454	93.67	gold quality
pancreas	UBERON:0001264	92.67	gold quality
esophagus mucosa	UBERON:0002469	92.16	gold quality
saliva-secreting gland	UBERON:0001044	91.47	gold quality
endometrium	UBERON:0001295	91.32	gold quality
intestine	UBERON:0000160	91.22	gold quality
minor salivary gland	UBERON:0001830	90.97	gold quality
colon	UBERON:0001155	90.44	gold quality
prostate gland	UBERON:0002367	89.88	gold quality
esophagus	UBERON:0001043	89.74	gold quality
tonsil	UBERON:0002372	89.31	gold quality
adult mammalian kidney	UBERON:0000082	89.29	gold quality
skin of abdomen	UBERON:0001416	88.43	gold quality
kidney	UBERON:0002113	88.40	gold quality
right lobe of thyroid gland	UBERON:0001119	87.11	gold quality
zone of skin	UBERON:0000014	86.61	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.96

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): ZEB2

Literature-anchored findings (GeneRIF, showing 40)

• study showed miR-200a, miR-200b & miR-429 in miR-200b-429 cluster are significantly associated with cancer recurrence & overall survival in advanced ovarian cancer; study suggests miR-200 miRNAs could play an important regulatory role in ovarian cancer (PMID:19501389)
• Data show that three members of the microRNA-200 family, miR200b, miR200c, and miR429 were predicted to have the highest scores. (PMID:19801681)
• Expression of miR-429 can break Epstein-Barr virus latency. (PMID:20484493)
• miR-200bc/429 cluster targets PLCgamma1 and differentially regulates proliferation and EGF-driven invasion than miR-200a/141 in breast cancer. (PMID:20514023)
• miRNAs 200b and 429 are key regulators via their effects on expression of ZEB1 and ZEB2 of the switch between latent and lytic infection by EBV (PMID:20668090)
• These findings implicate the miR-200 family and their targets, ZEB1 and ZEB2, as unique regulators of uterine quiescence and contractility during pregnancy and labor. (PMID:21079000)
• Ectopic overexpression of miR-429, a member of the miR-200 family of microRNAs, in mesenchymal-like OC cells resulted in reversal of the mesenchymal phenotype (mesenchymal-epithelial transition, MET). (PMID:21277012)
• Data show that Differentially expressed miRNAs including miR-99a, miR-100, miR-125b, miR-192, and miR-429 were detected in pancreatic cancer stem cells. (PMID:21785383)
• Overexpression of the differentially expressed miR-200 family member miR429 in MDA-MB231 cells attenuated their invasive stellate morphogenesis (PMID:22576799)
• miR-429 expression was up-regulated in human colorectal cancer tissues, and the high miR-429 expression was significantly associated with tumor size, lymph node metastasis and poor prognosis (PMID:23111103)
• MiR-141, miR-429 and miR-7-1-3p were significantly increased in seminal plasma of patients with non-obstructive azoospermia. (PMID:23559187)
• the ‘Focal adhesion’ and ‘ErbB signaling’ pathways were significantly regulated by miR-200b/c/429 and miR-200a/141, respectively. (PMID:23635949)
• The low expression of miR-429 correlated with poor prognosis for colorectal cancer. (PMID:24237355)
• our data showed that transcript factor Onecut2 is involved in the EMT, migration and invasion of CRC cells; miR-429 inhibits the initiation of EMT and regulated expression of EMT-related markers (PMID:24402783)
• miR-29c and miR-429, but not miR-93, may have a role in early stage non-small lung cancer (PMID:24523873)
• Epigenetic modification of miR-429 can manipulate liver T-ICs by targeting the RBBP4/E2F1/OCT4 axis (PMID:24572141)
• miR-429 serves as a tumor suppressor via interaction with ZEB1 (PMID:24633485)
• Findings indicate that the miR-200 family of microRNAs, and miR-429 in particular, play a critical role in the functioning of OC metastasizing cells. (PMID:24802724)
• Taken together, our results suggest that miR-429 plays an important role in promoting the proliferation and metastasis of NSCLC cells and is a potential target for NSCLC therapy. (PMID:24866238)
• Findings showed that miR-135a, -200b and -429 may take part in the progress of Alzheimers disease (PMID:25152461)
• The effect of miR-429 in prostate cancer cells was executed through targeting the p27Kip1 CDK inhibitor; p27Kip1 was demonstrated to be directly regulated by miR-429 in the cells. (PMID:25351256)
• We identified ZEB1 and CRKL as potential targets of miR-429 by analyzing combined results from in silico search and global expression array of the same RNA samples. Immunoblot assay confirmed that miR-429 reduced their expression at protein level. (PMID:25405387)
• miR-429 attenuates HIF-1 activity by decreasing HIF1A message during the early stages of hypoxia before HIF-2 is activated (PMID:25550463)
• MiR-429 inhibits oral squamous cell carcinoma growth by targeting ZEB1 (PMID:25640197)
• identified miR-200a, miR-200b and miR-429 as highly up-regulated onco-miRs in endometrioid endometrial carcinoma (PMID:25750291)
• 3’UTR of TBK1 was targeted by miR-429. Therefore, we concluded that low miR-429 level in PDAC promoted tumor cells growth which contributed to the low PDAC patients survival rate. (PMID:25833382)
• Results demonstrated that the miR-200b/200c/429 subfamily inhibited HCC cell migration through modulating Rho/ROCK mediated cell cytoskeletal reorganization and cell-substratum adhesion. (PMID:25909223)
• results here defined miR-429 as a key inducer for HCC pathogenesis and metastasis with potential utility for tumor intervention (PMID:25931210)
• 53BP1 functioned as a tumor suppressor gene by its novel negative control of Epithelial-mesenchymal transition through regulating the expression of miR-200b/429 and their target gene ZEB1. (PMID:26011542)
• the results of the present study suggested that miR-429 inhibits the migration and invasion of colon cancer cells, partly at least, by mediating the expression of PAK6, as well as the activity of cofilin signaling (PMID:26058485)
• Our results demonstrate that the p53 target miR-200b/200c/429 miRNAs are negative regulators of the CRKL oncogene (PMID:26079153)
• The results pf this study indicated that BMK1 modulation by miR-429 has an important function in glioma invasion both in vitro and in vivo. (PMID:26272601)
• Overexpression of miR-429 inhibited Bcl-2-mediated cell survival against apoptosis induced by Fluorouracil, while depletion of miR-429 augmented it. (PMID:26513239)
• downregulated miR429 functioned as a tumor suppressor by restraining cellular proliferation and migration, and inducing apoptosis, as well as targeting VEGF in Clear cell renal cell carcinoma cells. (PMID:26647818)
• Findings suggest that MIR429 modulates mucin secretion in human colorectal cells and mouse colitis tissues by up-regulating of MARCKS expression. (PMID:26818658)
• miR-429, was significantly up-regulated in glioma tissues. (PMID:26927341)
• MiR429 may act as a negative regulatory factor of nasopharyngeal carcinoma tumorigenesis, involving the functions of its downstream targets, zinc finger EBoxbinding homeobox 1 and CRKL. (PMID:26936585)
• This provides a compelling model for how hypoxia-induced miR-429 regulates the switch between HIF-1 adaptive responses to HIF-3 survival responses by rapidly decreasing HIF1A levels while simultaneously slowing the progression of HIF3A expression until the miR-429 levels drop below normoxic levels. (PMID:26954587)
• MiR-429 decreased the cell migratory and invasive abilities of urothelial cell carcinoma (UCC) cell lines (PMID:27058893)
• Downregulation of microRNA-429 protects cardiomyocytes against hypoxia-induced apoptosis by increasing Notch1 expression. (PMID:27082497)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.