MIR4290

Summary

MIR4290 (microRNA 4290, HGNC:38360) is a microRNA gene on chromosome 9q22.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422963 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38360
Approved symbol	MIR4290
Name	microRNA 4290
Location	9q22.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4290
Ensembl gene	ENSG00000263967
Ensembl biotype	miRNA
Entrez	100422963
RNAcentral	URS000075BBCF — miRNA, 95 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000583807

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000583807 — 1 exons

Exon	Start	End
ENSE00002708896	90023441	90023535

Expression profiles

Bgee: expression breadth broad, 12 present calls, max score 84.81.

Top tissues by expression

12 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	84.81	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	80.62	gold quality
stomach	UBERON:0000945	77.19	gold quality
blood	UBERON:0000178	76.70	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.69	gold quality
tibial nerve	UBERON:0001323	66.31	gold quality
left uterine tube	UBERON:0001303	61.94	gold quality
right hemisphere of cerebellum	UBERON:0014890	61.22	gold quality
lung	UBERON:0002048	59.16	gold quality
Brodmann (1909) area 9	UBERON:0013540	58.43	gold quality
left testis	UBERON:0004533	45.02	gold quality
right testis	UBERON:0004534	43.84	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.55

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• DLX6 Antisense RNA 1 Modulates Glucose Metabolism and Cell Growth in Gastric Cancer by Targeting microRNA-4290. (PMID:32239379)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.