MIR4291

Summary

MIR4291 (microRNA 4291, HGNC:38267) is a microRNA gene on chromosome 9q22.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422927 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38267
Approved symbol	MIR4291
Name	microRNA 4291
Location	9q22.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4291
Ensembl gene	ENSG00000265347
Ensembl biotype	miRNA
Entrez	100422927
RNAcentral	URS000075998A — ncRNA, 65 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000584984

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000584984 — 1 exons

Exon	Start	End
ENSE00002718033	93819357	93819421

Expression profiles

Bgee: expression breadth tissue_specific, 8 present calls, max score 75.18.

Top tissues by expression

8 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	75.18	gold quality
myometrium	UBERON:0001296	65.23	gold quality
subcutaneous adipose tissue	UBERON:0002190	63.02	gold quality
lung	UBERON:0002048	62.44	gold quality
adipose tissue	UBERON:0001013	61.87	gold quality
skin of leg	UBERON:0001511	61.61	gold quality
left testis	UBERON:0004533	42.28	gold quality
right testis	UBERON:0004534	39.17	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.17

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.