MIR4292

Summary

MIR4292 (microRNA 4292, HGNC:38348) is a microRNA gene on chromosome 9q34.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422860 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38348
Approved symbol	MIR4292
Name	microRNA 4292
Location	9q34.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4292
Ensembl gene	ENSG00000265806
Ensembl biotype	miRNA
Entrez	100422860
RNAcentral	URS000075E861 — ncRNA, 67 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000585012

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000585012 — 1 exons

Exon	Start	End
ENSE00002694234	136830957	136831023

Expression profiles

Bgee: expression breadth ubiquitous, 117 present calls, max score 96.47.

Top tissues by expression

117 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right hemisphere of cerebellum	UBERON:0014890	96.47	gold quality
cerebellar hemisphere	UBERON:0002245	95.83	gold quality
bone marrow	UBERON:0002371	95.57	gold quality
lower esophagus mucosa	UBERON:0035834	94.56	gold quality
pituitary gland	UBERON:0000007	94.17	gold quality
duodenum	UBERON:0002114	93.39	gold quality
skeletal muscle tissue	UBERON:0001134	93.23	gold quality
sural nerve	UBERON:0015488	93.22	gold quality
adenohypophysis	UBERON:0002196	92.63	gold quality
right uterine tube	UBERON:0001302	91.91	gold quality
granulocyte	CL:0000094	91.51	gold quality
right lobe of thyroid gland	UBERON:0001119	91.00	gold quality
endometrium	UBERON:0001295	90.60	gold quality
vermiform appendix	UBERON:0001154	90.54	gold quality
left ovary	UBERON:0002119	90.25	gold quality
prefrontal cortex	UBERON:0000451	90.11	gold quality
left lobe of thyroid gland	UBERON:0001120	90.05	gold quality
placenta	UBERON:0001987	90.01	gold quality
ovary	UBERON:0000992	89.99	gold quality
thyroid gland	UBERON:0002046	89.89	gold quality
right ovary	UBERON:0002118	89.68	gold quality
body of uterus	UBERON:0009853	89.62	gold quality
transverse colon	UBERON:0001157	89.44	gold quality
nucleus accumbens	UBERON:0001882	89.36	gold quality
prostate gland	UBERON:0002367	88.95	gold quality
right testis	UBERON:0004534	88.94	gold quality
rectum	UBERON:0001052	88.90	gold quality
small intestine	UBERON:0002108	88.90	gold quality
body of pancreas	UBERON:0001150	88.83	gold quality
right coronary artery	UBERON:0001625	88.80	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.39

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.