MIR4293

Summary

MIR4293 (microRNA 4293, HGNC:38270) is a microRNA gene on chromosome 10p13.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422843 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38270
Approved symbol	MIR4293
Name	microRNA 4293
Location	10p13
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4293
Ensembl gene	ENSG00000266321
Ensembl biotype	miRNA
Entrez	100422843
RNAcentral	URS000075C2F1 — miRNA, 78 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000584305

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000584305 — 1 exons

Exon	Start	End
ENSE00002728862	14383200	14383277

Expression profiles

Bgee: expression breadth tissue_specific, 10 present calls, max score 77.45.

Top tissues by expression

10 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	77.45	gold quality
monocyte	CL:0000576	73.68	gold quality
Brodmann (1909) area 9	UBERON:0013540	71.36	gold quality
substantia nigra	UBERON:0002038	64.76	gold quality
skin of abdomen	UBERON:0001416	63.50	gold quality
right frontal lobe	UBERON:0002810	61.72	gold quality
lung	UBERON:0002048	59.41	gold quality
left lobe of thyroid gland	UBERON:0001120	58.24	gold quality
corpus callosum	UBERON:0002336	56.39	gold quality
colon	UBERON:0001155	47.53	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 6)

• This study provides the first evidence that miR-449b rs10061133 and miR-4293 rs12220909 are associated with esophageal squamous cell carcinoma risk in Chinese population. (PMID:26055141)
• The GC/CC genotypes of miR-4293 rs12220909 were associated significantly with decreased non-small cell lung cancer susceptibility, which indicates that the mutant allele C of rs12220909 can influence the function of miR-4293. (PMID:28410417)
• Whether miR-4293 rs12220909 variant affects cancer susceptibility: evidence from 11255 subjects. (PMID:32496828)
• Association of miR-4293 rs12220909 polymorphism with cancer risk: A meta-analysis of 8394 subjects. (PMID:32769868)
• miR-4293 upregulates lncRNA WFDC21P by suppressing mRNA-decapping enzyme 2 to promote lung carcinoma proliferation. (PMID:34301920)
• Novel susceptibility loci for steroid-associated osteonecrosis of the femoral head in systemic lupus erythematosus. (PMID:34850884)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.