MIR4294

Summary

MIR4294 (microRNA 4294, HGNC:38180) is a microRNA gene on chromosome 10q11.23.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422895 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38180
Approved symbol	MIR4294
Name	microRNA 4294
Location	10q11.23
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4294
Ensembl gene	ENSG00000264800
Ensembl biotype	miRNA
Entrez	100422895
RNAcentral	URS000075D602 — miRNA, 76 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000584548

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000584548 — 1 exons

Exon	Start	End
ENSE00002705838	48985512	48985587

Expression profiles

Bgee: expression breadth broad, 78 present calls, max score 87.01.

Top tissues by expression

78 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	87.01	gold quality
lymph node	UBERON:0000029	76.36	gold quality
blood	UBERON:0000178	75.99	gold quality
monocyte	CL:0000576	75.83	gold quality
muscle of leg	UBERON:0001383	73.89	gold quality
gastrocnemius	UBERON:0001388	72.82	gold quality
fundus of stomach	UBERON:0001160	72.33	gold quality
kidney	UBERON:0002113	69.98	gold quality
tonsil	UBERON:0002372	69.84	gold quality
right atrium auricular region	UBERON:0006631	69.76	gold quality
heart left ventricle	UBERON:0002084	69.68	gold quality
right lobe of liver	UBERON:0001114	69.51	gold quality
left adrenal gland cortex	UBERON:0035825	68.78	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	68.63	gold quality
left adrenal gland	UBERON:0001234	68.10	gold quality
tibial artery	UBERON:0007610	68.00	gold quality
popliteal artery	UBERON:0002250	67.97	gold quality
ascending aorta	UBERON:0001496	67.72	gold quality
right adrenal gland	UBERON:0001233	67.70	gold quality
stomach	UBERON:0000945	67.59	gold quality
endometrium	UBERON:0001295	67.52	gold quality
thoracic aorta	UBERON:0001515	67.44	gold quality
right lobe of thyroid gland	UBERON:0001119	67.41	gold quality
body of stomach	UBERON:0001161	67.37	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	66.33	gold quality
right adrenal gland cortex	UBERON:0035827	66.32	gold quality
transverse colon	UBERON:0001157	66.23	gold quality
saliva-secreting gland	UBERON:0001044	66.03	gold quality
left coronary artery	UBERON:0001626	66.02	gold quality
anterior cingulate cortex	UBERON:0009835	65.81	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.17

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.