MIR4295

Summary

MIR4295 (microRNA 4295, HGNC:38220) is a microRNA gene on chromosome 10q25.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422909 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38220
Approved symbol	MIR4295
Name	microRNA 4295
Location	10q25.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4295
Ensembl gene	ENSG00000264763
Ensembl biotype	miRNA
Entrez	100422909
RNAcentral	URS000075E4DB — ncRNA, 85 nt, 8 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000585286

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000585286 — 1 exons

Exon	Start	End
ENSE00002730812	112634170	112634254

Expression profiles

Bgee: expression breadth broad, 57 present calls, max score 85.10.

Top tissues by expression

57 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
kidney	UBERON:0002113	85.10	gold quality
adrenal tissue	UBERON:0018303	81.61	gold quality
blood	UBERON:0000178	81.43	gold quality
bone marrow	UBERON:0002371	80.47	gold quality
liver	UBERON:0002107	79.29	gold quality
monocyte	CL:0000576	78.17	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	74.90	gold quality
stomach	UBERON:0000945	73.38	gold quality
gastrocnemius	UBERON:0001388	72.96	gold quality
heart	UBERON:0000948	72.67	gold quality
endometrium	UBERON:0001295	72.49	gold quality
body of stomach	UBERON:0001161	71.03	gold quality
lung	UBERON:0002048	70.73	gold quality
right atrium auricular region	UBERON:0006631	69.41	gold quality
tibial artery	UBERON:0007610	67.84	gold quality
heart left ventricle	UBERON:0002084	67.72	gold quality
caudate nucleus	UBERON:0001873	67.11	gold quality
body of pancreas	UBERON:0001150	66.93	gold quality
amygdala	UBERON:0001876	66.43	gold quality
right adrenal gland	UBERON:0001233	66.41	gold quality
thoracic aorta	UBERON:0001515	66.38	gold quality
ascending aorta	UBERON:0001496	66.20	gold quality
skin of leg	UBERON:0001511	65.76	gold quality
left adrenal gland	UBERON:0001234	65.70	gold quality
corpus callosum	UBERON:0002336	65.56	gold quality
substantia nigra	UBERON:0002038	65.45	gold quality
intestine	UBERON:0000160	65.41	gold quality
lower esophagus muscularis layer	UBERON:0035833	65.12	gold quality
transverse colon	UBERON:0001157	65.05	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	64.38	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.65

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 8)

• Data indicte that deubiquitinating enzyme USP28 was targeted by microRNA miR-4295. (PMID:25656529)
• N-myc protein also could bind to the promoter of pri-miR-4295 and inhibit the expression of RUNX3 in glioma cells. (PMID:26756701)
• the RING domain of XIAP has a role in promoting miR-4295 transcription, which reduces p63alpha translation and enhances urothelial transformation (PMID:27447744)
• Taken together, our results suggest GPC5 as a tumor suppressor in PDAC and its expression is possibly regulated by miR-4295. Our study indicates that the miR-4295/GPC5 axis may play an important role in the pathogenesis of PADC and has potential applications for the development of PDAC therapy. (PMID:29407175)
• GRh2 dose-dependently inhibited prostate cancer cell proliferation, but did not alter cell apoptosis, seemingly through downregulation of miR-4295, which inhibits protein translation of CDKN1A. (PMID:29457293)
• MiR-4295 facilitates cell proliferation and metastasis in head and neck squamous cell carcinoma by targeting NPTX1. (PMID:31118494)
• PTPN14, a target gene of miR-4295, restricts the growth and invasion of osteosarcoma cells through inactivation of YAP1 signalling. (PMID:32141101)
• miR-4295 Promotes the Malignant Progression of Gastric Cancer via Targeting PTEN. (PMID:34758714)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.