MIR4296

Summary

MIR4296 (microRNA 4296, HGNC:38178) is a microRNA gene on chromosome 10q26.13.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100423041 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38178
Approved symbol	MIR4296
Name	microRNA 4296
Location	10q26.13
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4296
Ensembl gene	ENSG00000264572
Ensembl biotype	miRNA
Entrez	100423041
RNAcentral	URS000075C881 — ncRNA, 88 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000581038

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000581038 — 1 exons

Exon	Start	End
ENSE00002712483	125032783	125032870

Expression profiles

Bgee: expression breadth broad, 86 present calls, max score 84.21.

Top tissues by expression

86 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	84.21	gold quality
blood	UBERON:0000178	82.38	gold quality
bone marrow	UBERON:0002371	79.35	gold quality
fundus of stomach	UBERON:0001160	75.96	gold quality
monocyte	CL:0000576	75.71	gold quality
stomach	UBERON:0000945	74.45	gold quality
sural nerve	UBERON:0015488	73.91	gold quality
muscle of leg	UBERON:0001383	73.85	gold quality
gastrocnemius	UBERON:0001388	73.70	gold quality
liver	UBERON:0002107	72.67	gold quality
kidney	UBERON:0002113	70.97	gold quality
heart	UBERON:0000948	70.88	gold quality
adrenal gland	UBERON:0002369	70.85	gold quality
adult mammalian kidney	UBERON:0000082	70.66	gold quality
heart left ventricle	UBERON:0002084	70.51	gold quality
lung	UBERON:0002048	70.34	gold quality
endometrium	UBERON:0001295	70.18	gold quality
right atrium auricular region	UBERON:0006631	70.11	gold quality
corpus callosum	UBERON:0002336	69.86	gold quality
pancreas	UBERON:0001264	69.37	gold quality
granulocyte	CL:0000094	68.58	gold quality
descending thoracic aorta	UBERON:0002345	68.46	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.36	gold quality
body of stomach	UBERON:0001161	68.35	gold quality
right coronary artery	UBERON:0001625	68.10	gold quality
body of pancreas	UBERON:0001150	68.02	gold quality
left adrenal gland	UBERON:0001234	67.89	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.74	gold quality
intestine	UBERON:0000160	67.56	gold quality
tibial artery	UBERON:0007610	67.49	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.16

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.