MIR4297

Summary

MIR4297 (microRNA 4297, HGNC:38393) is a microRNA gene on chromosome 10q26.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422873 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38393
Approved symbol	MIR4297
Name	microRNA 4297
Location	10q26.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4297
Ensembl gene	ENSG00000266676
Ensembl biotype	miRNA
Entrez	100422873
RNAcentral	URS000075EB7F — ncRNA, 76 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000579857

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000579857 — 1 exons

Exon	Start	End
ENSE00002702255	129843299	129843374

Expression profiles

Bgee: expression breadth broad, 98 present calls, max score 87.42.

Top tissues by expression

98 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skeletal muscle tissue	UBERON:0001134	87.42	gold quality
calcaneal tendon	UBERON:0003701	82.89	gold quality
right uterine tube	UBERON:0001302	81.82	gold quality
right lobe of liver	UBERON:0001114	76.78	gold quality
endometrium	UBERON:0001295	76.61	gold quality
muscle of leg	UBERON:0001383	76.45	gold quality
subcutaneous adipose tissue	UBERON:0002190	76.31	gold quality
placenta	UBERON:0001987	75.72	gold quality
liver	UBERON:0002107	75.43	gold quality
gastrocnemius	UBERON:0001388	75.37	gold quality
right ovary	UBERON:0002118	75.20	gold quality
gall bladder	UBERON:0002110	75.00	gold quality
adipose tissue	UBERON:0001013	74.52	gold quality
right atrium auricular region	UBERON:0006631	73.62	gold quality
urinary bladder	UBERON:0001255	73.48	gold quality
blood	UBERON:0000178	72.97	gold quality
thoracic mammary gland	UBERON:0005200	72.94	gold quality
heart	UBERON:0000948	72.89	gold quality
tibial nerve	UBERON:0001323	72.81	gold quality
heart left ventricle	UBERON:0002084	72.70	gold quality
ovary	UBERON:0000992	72.24	gold quality
omental fat pad	UBERON:0010414	72.15	gold quality
fallopian tube	UBERON:0003889	71.66	gold quality
monocyte	CL:0000576	71.64	gold quality
left ovary	UBERON:0002119	71.62	gold quality
endocervix	UBERON:0000458	71.52	gold quality
islet of Langerhans	UBERON:0000006	71.33	gold quality
right adrenal gland	UBERON:0001233	71.33	gold quality
fundus of stomach	UBERON:0001160	70.85	gold quality
left coronary artery	UBERON:0001626	70.78	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.09

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.