MIR4298

Summary

MIR4298 (microRNA 4298, HGNC:38313) is a microRNA gene on chromosome 11p15.5.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100423021 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38313
Approved symbol	MIR4298
Name	microRNA 4298
Location	11p15.5
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4298
Ensembl gene	ENSG00000264493
Ensembl biotype	miRNA
Entrez	100423021
RNAcentral	URS000075ED1A — ncRNA, 73 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000584380

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000584380 — 1 exons

Exon	Start	End
ENSE00002687578	1859464	1859536

Expression profiles

Bgee: expression breadth broad, 75 present calls, max score 95.21.

Top tissues by expression

75 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	95.21	gold quality
skeletal muscle tissue	UBERON:0001134	88.11	gold quality
bone marrow	UBERON:0002371	83.39	gold quality
blood	UBERON:0000178	83.28	gold quality
calcaneal tendon	UBERON:0003701	79.94	gold quality
spleen	UBERON:0002106	78.50	gold quality
lymph node	UBERON:0000029	77.68	gold quality
adrenal tissue	UBERON:0018303	77.06	gold quality
tonsil	UBERON:0002372	75.94	gold quality
muscle of leg	UBERON:0001383	75.60	gold quality
monocyte	CL:0000576	75.59	gold quality
left adrenal gland	UBERON:0001234	75.50	gold quality
hypothalamus	UBERON:0001898	75.28	gold quality
left adrenal gland cortex	UBERON:0035825	74.44	gold quality
gastrocnemius	UBERON:0001388	73.73	gold quality
placenta	UBERON:0001987	73.47	gold quality
right adrenal gland cortex	UBERON:0035827	73.14	gold quality
right adrenal gland	UBERON:0001233	72.31	gold quality
anterior cingulate cortex	UBERON:0009835	71.95	gold quality
multicellular organism	UBERON:0000468	71.41	gold quality
endometrium	UBERON:0001295	70.70	gold quality
right atrium auricular region	UBERON:0006631	69.25	gold quality
body of stomach	UBERON:0001161	69.01	gold quality
liver	UBERON:0002107	68.56	gold quality
myometrium	UBERON:0001296	68.23	gold quality
left coronary artery	UBERON:0001626	67.98	gold quality
Ammon’s horn	UBERON:0001954	67.79	gold quality
right coronary artery	UBERON:0001625	67.47	gold quality
body of uterus	UBERON:0009853	67.35	gold quality
stomach	UBERON:0000945	67.20	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.57

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.