MIR4299

Summary

MIR4299 (microRNA 4299, HGNC:38329) is a microRNA gene on chromosome 11p15.4.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100423026 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38329
Approved symbol	MIR4299
Name	microRNA 4299
Location	11p15.4
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4299
Ensembl gene	ENSG00000266645
Ensembl biotype	miRNA
Entrez	100423026
RNAcentral	URS000075EC98 — miRNA, 72 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000577899

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000577899 — 1 exons

Exon	Start	End
ENSE00002731357	11656651	11656722

Expression profiles

Bgee: expression breadth broad, 33 present calls, max score 85.18.

Top tissues by expression

33 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
placenta	UBERON:0001987	85.18	gold quality
intestine	UBERON:0000160	83.92	gold quality
stomach	UBERON:0000945	75.54	gold quality
heart	UBERON:0000948	72.87	gold quality
putamen	UBERON:0001874	72.34	gold quality
heart left ventricle	UBERON:0002084	72.32	gold quality
endometrium	UBERON:0001295	70.55	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.37	gold quality
right atrium auricular region	UBERON:0006631	67.34	gold quality
substantia nigra	UBERON:0002038	67.18	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	66.01	gold quality
tibial artery	UBERON:0007610	65.02	gold quality
Ammon’s horn	UBERON:0001954	64.88	gold quality
omental fat pad	UBERON:0010414	64.13	gold quality
hypothalamus	UBERON:0001898	63.86	gold quality
right frontal lobe	UBERON:0002810	63.73	gold quality
nucleus accumbens	UBERON:0001882	63.11	gold quality
left uterine tube	UBERON:0001303	63.07	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	62.78	gold quality
prostate gland	UBERON:0002367	62.67	gold quality
subcutaneous adipose tissue	UBERON:0002190	62.56	gold quality
tibial nerve	UBERON:0001323	61.87	gold quality
skin of leg	UBERON:0001511	61.60	gold quality
skin of abdomen	UBERON:0001416	61.43	gold quality
brain	UBERON:0000955	61.19	gold quality
left ovary	UBERON:0002119	60.67	gold quality
Brodmann (1909) area 9	UBERON:0013540	57.98	gold quality
pituitary gland	UBERON:0000007	56.13	gold quality
caudate nucleus	UBERON:0001873	55.35	gold quality
testis	UBERON:0000473	44.23	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• The low level of miR-4299 expression is correlated with less chemotherapy resistance and better survival of colon cancer patients. (PMID:26626874)
• This study implies the potential therapeutic application of miR-4299 and ST6GALNAC4 in modulating the invasion and tumorigenicity of follicular thyroid carcinoma cell (PMID:26715099)
• results indicate that miR-4299 may be a candidate independent marker for NSCLC prognosis and suppressed the progression of NSCLC by modulating the activation of PTEN/AKT/PI3K signaling pathway. (PMID:29917192)
• miR-4299 inhibits tumor progression in pancreatic cancer through targeting ADAM17. (PMID:36565360)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.