MIR4300

Summary

MIR4300 (microRNA 4300, HGNC:38184) is a microRNA gene on chromosome 11q14.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422823 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38184
Approved symbol	MIR4300
Name	microRNA 4300
Location	11q14.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4300
Ensembl gene	ENSG00000264110
Ensembl biotype	miRNA
Entrez	100422823
RNAcentral	URS000075C0A4 — miRNA, 96 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000581016

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000581016 — 1 exons

Exon	Start	End
ENSE00002727569	81890741	81890836

Expression profiles

Bgee: expression breadth broad, 22 present calls, max score 86.20.

Top tissues by expression

22 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
intestine	UBERON:0000160	86.20	gold quality
monocyte	CL:0000576	77.94	gold quality
right hemisphere of cerebellum	UBERON:0014890	70.61	gold quality
Ammon’s horn	UBERON:0001954	70.21	gold quality
lung	UBERON:0002048	70.12	gold quality
skin of leg	UBERON:0001511	68.74	gold quality
body of stomach	UBERON:0001161	68.57	gold quality
Brodmann (1909) area 9	UBERON:0013540	67.86	gold quality
cerebellar hemisphere	UBERON:0002245	67.61	gold quality
amygdala	UBERON:0001876	66.40	gold quality
caudate nucleus	UBERON:0001873	66.38	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	66.36	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	66.18	gold quality
left lobe of thyroid gland	UBERON:0001120	65.94	gold quality
substantia nigra	UBERON:0002038	65.61	gold quality
upper lobe of left lung	UBERON:0008952	64.54	gold quality
skin of abdomen	UBERON:0001416	63.61	gold quality
prostate gland	UBERON:0002367	62.14	gold quality
corpus callosum	UBERON:0002336	56.16	gold quality
right frontal lobe	UBERON:0002810	51.03	gold quality
right testis	UBERON:0004534	46.32	gold quality
left testis	UBERON:0004533	45.28	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.99

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• In silico and in vitro analyses identified a functional variant, rs35333564 in MIR4300HG, the host gene of a microRNA, MIR4300. The genomic region containing rs35333564 had enhancer activity, which was decreased in its risk allele. Data suggest that decrease of MIR4300 is related to AIS progression. (PMID:29016859)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.