MIR4301

Summary

MIR4301 (microRNA 4301, HGNC:38323) is a microRNA gene on chromosome 11q23.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422855 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38323
Approved symbol	MIR4301
Name	microRNA 4301
Location	11q23.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4301
Ensembl gene	ENSG00000265140
Ensembl biotype	miRNA
Entrez	100422855
RNAcentral	URS000075A09B — miRNA, 66 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000577203

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000577203 — 1 exons

Exon	Start	End
ENSE00002714647	113450023	113450088

Expression profiles

Bgee: expression breadth broad, 34 present calls, max score 76.35.

Top tissues by expression

34 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
heart	UBERON:0000948	76.35	gold quality
muscle of leg	UBERON:0001383	74.73	gold quality
amygdala	UBERON:0001876	73.45	gold quality
gastrocnemius	UBERON:0001388	73.39	gold quality
lower esophagus muscularis layer	UBERON:0035833	73.14	gold quality
calcaneal tendon	UBERON:0003701	71.68	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	70.26	gold quality
skin of leg	UBERON:0001511	68.47	gold quality
right frontal lobe	UBERON:0002810	68.27	gold quality
monocyte	CL:0000576	67.45	gold quality
fallopian tube	UBERON:0003889	67.24	gold quality
body of pancreas	UBERON:0001150	67.15	gold quality
hypothalamus	UBERON:0001898	67.02	gold quality
putamen	UBERON:0001874	66.44	gold quality
caudate nucleus	UBERON:0001873	65.76	gold quality
subcutaneous adipose tissue	UBERON:0002190	65.56	gold quality
intestine	UBERON:0000160	65.53	gold quality
left adrenal gland	UBERON:0001234	65.27	gold quality
transverse colon	UBERON:0001157	65.14	gold quality
nucleus accumbens	UBERON:0001882	64.47	gold quality
left lobe of thyroid gland	UBERON:0001120	64.20	gold quality
right hemisphere of cerebellum	UBERON:0014890	63.76	gold quality
skin of abdomen	UBERON:0001416	63.53	gold quality
cerebellar hemisphere	UBERON:0002245	63.26	gold quality
tibial nerve	UBERON:0001323	62.13	gold quality
minor salivary gland	UBERON:0001830	61.84	gold quality
pituitary gland	UBERON:0000007	61.71	gold quality
muscle layer of sigmoid colon	UBERON:0035805	61.53	gold quality
esophagus mucosa	UBERON:0002469	60.33	gold quality
anterior cingulate cortex	UBERON:0009835	59.98	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• Expression analysis indicated that miR-4301 was inversely correlated with DRD2 expression in breast cancer specimens. qRT-PCR showed that miR-4301 negatively regulated DRD2 expression. Downregulation of DRD2 expression in MDA-MB-231, MCF-7, and SKBR3 cells suppressed cell proliferation and promoted apoptosis. (PMID:29236292)
• LncRNA LACAT1 promotes proliferation of oral squamous cell carcinoma cells by inhibiting microRNA-4301. (PMID:30964168)
• Host miR-4301 promotes rotavirus replication via PPP1R3D in Caco-2 cells. (PMID:34260071)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.