MIR4304

Summary

MIR4304 (microRNA 4304, HGNC:38276) is a microRNA gene on chromosome 12q24.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422931 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38276
Approved symbol	MIR4304
Name	microRNA 4304
Location	12q24.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4304
Ensembl gene	ENSG00000265526
Ensembl biotype	miRNA
Entrez	100422931
RNAcentral	URS000075A30A — ncRNA, 62 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000580964

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000580964 — 1 exons

Exon	Start	End
ENSE00002691877	123010667	123010728

Expression profiles

Bgee: expression breadth broad, 65 present calls, max score 84.39.

Top tissues by expression

65 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	84.39	gold quality
bone marrow	UBERON:0002371	80.85	gold quality
stomach	UBERON:0000945	80.36	gold quality
blood	UBERON:0000178	79.51	gold quality
liver	UBERON:0002107	75.65	gold quality
tibial artery	UBERON:0007610	75.27	gold quality
gastrocnemius	UBERON:0001388	75.13	gold quality
calcaneal tendon	UBERON:0003701	75.06	gold quality
adult mammalian kidney	UBERON:0000082	74.41	gold quality
right lobe of liver	UBERON:0001114	74.38	gold quality
monocyte	CL:0000576	72.36	gold quality
Ammon’s horn	UBERON:0001954	71.06	gold quality
heart	UBERON:0000948	70.37	gold quality
right adrenal gland cortex	UBERON:0035827	70.14	gold quality
body of stomach	UBERON:0001161	69.54	gold quality
heart left ventricle	UBERON:0002084	69.26	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.93	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.71	gold quality
body of pancreas	UBERON:0001150	68.32	gold quality
left uterine tube	UBERON:0001303	68.29	gold quality
muscle layer of sigmoid colon	UBERON:0035805	68.22	gold quality
endometrium	UBERON:0001295	68.19	gold quality
skin of abdomen	UBERON:0001416	67.96	gold quality
omental fat pad	UBERON:0010414	67.51	gold quality
left coronary artery	UBERON:0001626	67.46	gold quality
myometrium	UBERON:0001296	67.28	gold quality
esophagus mucosa	UBERON:0002469	67.15	gold quality
ascending aorta	UBERON:0001496	67.14	gold quality
amygdala	UBERON:0001876	67.11	gold quality
body of uterus	UBERON:0009853	66.87	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.23

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.