MIR4305

Summary

MIR4305 (microRNA 4305, HGNC:38301) is a microRNA gene on chromosome 13q14.11.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422940 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38301
Approved symbol	MIR4305
Name	microRNA 4305
Location	13q14.11
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4305
Ensembl gene	ENSG00000264171
Ensembl biotype	miRNA
Entrez	100422940
RNAcentral	URS000075AD73 — ncRNA, 102 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000583252

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000583252 — 1 exons

Exon	Start	End
ENSE00002731887	39664034	39664135

Expression profiles

Bgee: expression breadth broad, 67 present calls, max score 78.71.

Top tissues by expression

67 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	78.71	gold quality
stomach	UBERON:0000945	76.75	gold quality
adrenal tissue	UBERON:0018303	76.64	gold quality
monocyte	CL:0000576	76.30	gold quality
adult mammalian kidney	UBERON:0000082	74.81	gold quality
kidney	UBERON:0002113	74.42	gold quality
endometrium	UBERON:0001295	74.12	gold quality
liver	UBERON:0002107	72.97	gold quality
tibial artery	UBERON:0007610	72.33	gold quality
lung	UBERON:0002048	71.63	gold quality
heart	UBERON:0000948	71.58	gold quality
body of pancreas	UBERON:0001150	70.79	gold quality
calcaneal tendon	UBERON:0003701	70.68	gold quality
left adrenal gland cortex	UBERON:0035825	70.57	gold quality
colon	UBERON:0001155	70.26	gold quality
ascending aorta	UBERON:0001496	70.07	gold quality
intestine	UBERON:0000160	69.97	gold quality
right coronary artery	UBERON:0001625	69.90	gold quality
body of uterus	UBERON:0009853	69.69	gold quality
left coronary artery	UBERON:0001626	69.31	gold quality
esophagus mucosa	UBERON:0002469	69.02	gold quality
body of stomach	UBERON:0001161	69.01	gold quality
gastrocnemius	UBERON:0001388	68.80	gold quality
right lobe of liver	UBERON:0001114	68.71	gold quality
right atrium auricular region	UBERON:0006631	68.62	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.62	gold quality
subcutaneous adipose tissue	UBERON:0002190	67.99	gold quality
heart left ventricle	UBERON:0002084	67.63	gold quality
thoracic mammary gland	UBERON:0005200	67.46	gold quality
Ammon’s horn	UBERON:0001954	67.36	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.35

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.