MIR4306

Summary

MIR4306 (microRNA 4306, HGNC:38350) is a microRNA gene on chromosome 13q32.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422861 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38350
Approved symbol	MIR4306
Name	microRNA 4306
Location	13q32.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4306
Ensembl gene	ENSG00000263615
Ensembl biotype	miRNA
Entrez	100422861
RNAcentral	URS000075A81F — miRNA, 91 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000583390

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000583390 — 1 exons

Exon	Start	End
ENSE00002686034	99643059	99643149

Expression profiles

Bgee: expression breadth broad, 58 present calls, max score 91.73.

Top tissues by expression

58 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adult mammalian kidney	UBERON:0000082	91.73	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	88.65	gold quality
kidney	UBERON:0002113	82.36	gold quality
blood	UBERON:0000178	82.10	gold quality
liver	UBERON:0002107	78.81	gold quality
anterior cingulate cortex	UBERON:0009835	76.37	gold quality
adrenal tissue	UBERON:0018303	75.37	gold quality
stomach	UBERON:0000945	75.35	gold quality
monocyte	CL:0000576	73.86	gold quality
body of uterus	UBERON:0009853	73.37	gold quality
left adrenal gland cortex	UBERON:0035825	72.11	gold quality
calcaneal tendon	UBERON:0003701	72.06	gold quality
right lobe of liver	UBERON:0001114	71.25	gold quality
tibial artery	UBERON:0007610	71.10	gold quality
putamen	UBERON:0001874	70.43	gold quality
intestine	UBERON:0000160	68.70	gold quality
ascending aorta	UBERON:0001496	68.53	gold quality
tonsil	UBERON:0002372	68.06	gold quality
subcutaneous adipose tissue	UBERON:0002190	67.69	gold quality
transverse colon	UBERON:0001157	67.68	gold quality
body of pancreas	UBERON:0001150	67.46	gold quality
colon	UBERON:0001155	67.30	gold quality
lung	UBERON:0002048	67.09	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.09	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	66.91	gold quality
Ammon’s horn	UBERON:0001954	65.87	gold quality
muscle layer of sigmoid colon	UBERON:0035805	65.73	gold quality
vagina	UBERON:0000996	65.42	gold quality
minor salivary gland	UBERON:0001830	65.09	gold quality
skin of abdomen	UBERON:0001416	65.06	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.57

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 10)

• The level of miR-4306 was significantly increased in Arteriosclerosis Obliterans. (PMID:26370316)
• ATP13A2 inhibition by hsa-miR-4306 efficiently restored manganese-induced cytotoxicity in cultured neurons. (PMID:28302480)
• In conclusion, our study suggested that intercellular transfer of miR-4306 by platelet microparticles inhibited the HMDMs migration through VEGFA/ERK1/2/ NF-kappaB signaling pathways. (PMID:30183452)
• Regulation of capillary tubules and lipid formation in vascular endothelial cells and macrophages via extracellular vesicle-mediated microRNA-4306 transfer has been reported. (PMID:30477383)
• These findings suggest that miR-4306 acts as a tumor suppressor in triple-negative breast cancer and is a potential therapeutic target for triple-negative breast cancer treatment. (PMID:30867840)
• LncRNA LINC00958 promotes tumor progression through miR-4306/CEMIP axis in osteosarcoma. (PMID:33928604)
• miR-4306 Suppresses Proliferation of Esophageal Squamous Cell Carcinoma Cell by Targeting SIX3. (PMID:34021861)
• The regulation of long non-coding RNA 00958 (LINC00958) for oral squamous cell carcinoma (OSCC) cells death through absent in melanoma 2 (AIM2) depending on microRNA-4306 and Sirtuin1 (SIRT1) in vitro. (PMID:34384029)
• CircAGFG1 acts as a sponge of miR-4306 to stimulate esophageal cancer progression by modulating MAPRE2 expression. (PMID:34461454)
• The role of the miR-4306/PAK6 axis in degenerative nucleus pulposus cells in human intervertebral disc degeneration. (PMID:36423859)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.