MIR4307

Summary

MIR4307 (microRNA 4307, HGNC:38257) is a microRNA gene on chromosome 14q12.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100423019 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38257
Approved symbol	MIR4307
Name	microRNA 4307
Location	14q12
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4307
Ensembl gene	ENSG00000265165
Ensembl biotype	miRNA
Entrez	100423019
RNAcentral	URS000075C3CA — ncRNA, 84 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000582802

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000582802 — 1 exons

Exon	Start	End
ENSE00002731028	26908642	26908725

Expression profiles

Bgee: expression breadth broad, 46 present calls, max score 79.95.

Top tissues by expression

46 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
kidney	UBERON:0002113	79.95	gold quality
stomach	UBERON:0000945	79.11	gold quality
endometrium	UBERON:0001295	79.00	gold quality
adult mammalian kidney	UBERON:0000082	77.71	gold quality
monocyte	CL:0000576	76.82	gold quality
tibial artery	UBERON:0007610	73.77	gold quality
gastrocnemius	UBERON:0001388	73.20	gold quality
intestine	UBERON:0000160	71.91	gold quality
body of pancreas	UBERON:0001150	71.18	gold quality
skin of leg	UBERON:0001511	69.68	gold quality
heart	UBERON:0000948	69.41	gold quality
right atrium auricular region	UBERON:0006631	68.48	gold quality
colon	UBERON:0001155	67.94	gold quality
thoracic mammary gland	UBERON:0005200	67.55	gold quality
transverse colon	UBERON:0001157	67.48	gold quality
ascending aorta	UBERON:0001496	67.17	gold quality
skin of abdomen	UBERON:0001416	66.86	gold quality
heart left ventricle	UBERON:0002084	66.41	gold quality
right frontal lobe	UBERON:0002810	66.27	gold quality
amygdala	UBERON:0001876	65.16	gold quality
left ovary	UBERON:0002119	65.07	gold quality
anterior cingulate cortex	UBERON:0009835	64.95	gold quality
left adrenal gland	UBERON:0001234	64.93	gold quality
right lobe of liver	UBERON:0001114	64.92	gold quality
subcutaneous adipose tissue	UBERON:0002190	64.92	gold quality
cerebral cortex	UBERON:0000956	64.54	gold quality
nucleus accumbens	UBERON:0001882	64.48	gold quality
esophagus mucosa	UBERON:0002469	63.99	gold quality
Brodmann (1909) area 9	UBERON:0013540	63.80	gold quality
right ovary	UBERON:0002118	63.22	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.20

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.