MIR4308

Summary

MIR4308 (microRNA 4308, HGNC:38206) is a microRNA gene on chromosome 14q22.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422984 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38206
Approved symbol	MIR4308
Name	microRNA 4308
Location	14q22.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4308
Ensembl gene	ENSG00000265432
Ensembl biotype	miRNA
Entrez	100422984
RNAcentral	URS000075C52F — miRNA, 81 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000580634

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000580634 — 1 exons

Exon	Start	End
ENSE00002710616	54878113	54878193

Expression profiles

Bgee: expression breadth broad, 49 present calls, max score 84.81.

Top tissues by expression

49 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
liver	UBERON:0002107	84.81	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	82.17	gold quality
adrenal tissue	UBERON:0018303	80.72	gold quality
right lobe of liver	UBERON:0001114	77.99	gold quality
blood	UBERON:0000178	77.31	gold quality
bone marrow	UBERON:0002371	74.85	gold quality
monocyte	CL:0000576	74.53	gold quality
calcaneal tendon	UBERON:0003701	74.28	gold quality
heart	UBERON:0000948	72.41	gold quality
body of pancreas	UBERON:0001150	72.12	gold quality
adult mammalian kidney	UBERON:0000082	71.02	gold quality
right atrium auricular region	UBERON:0006631	70.76	gold quality
stomach	UBERON:0000945	70.62	gold quality
heart left ventricle	UBERON:0002084	69.78	gold quality
left ovary	UBERON:0002119	69.70	gold quality
left adrenal gland cortex	UBERON:0035825	68.82	gold quality
tibial artery	UBERON:0007610	68.52	gold quality
multicellular organism	UBERON:0000468	67.83	gold quality
left adrenal gland	UBERON:0001234	67.52	gold quality
omental fat pad	UBERON:0010414	65.98	gold quality
putamen	UBERON:0001874	65.48	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	65.33	gold quality
body of stomach	UBERON:0001161	65.19	gold quality
intestine	UBERON:0000160	65.04	gold quality
nucleus accumbens	UBERON:0001882	65.04	gold quality
skin of leg	UBERON:0001511	64.89	gold quality
transverse colon	UBERON:0001157	64.11	gold quality
anterior cingulate cortex	UBERON:0009835	63.60	gold quality
skin of abdomen	UBERON:0001416	63.07	gold quality
esophagus mucosa	UBERON:0002469	62.92	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.99

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.