MIR4309

Summary

MIR4309 (microRNA 4309, HGNC:38336) is a microRNA gene on chromosome 14q32.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422954 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38336
Approved symbol	MIR4309
Name	microRNA 4309
Location	14q32.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4309
Ensembl gene	ENSG00000266015
Ensembl biotype	miRNA
Entrez	100422954
RNAcentral	URS000075AF0F — ncRNA, 83 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000582498

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000582498 — 1 exons

Exon	Start	End
ENSE00002689128	102539644	102539726

Expression profiles

Bgee: expression breadth broad, 19 present calls, max score 84.79.

Top tissues by expression

19 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	84.79	gold quality
gastrocnemius	UBERON:0001388	74.47	gold quality
blood	UBERON:0000178	74.39	gold quality
esophagus mucosa	UBERON:0002469	67.84	gold quality
lung	UBERON:0002048	65.83	gold quality
right frontal lobe	UBERON:0002810	65.11	gold quality
omental fat pad	UBERON:0010414	64.70	gold quality
body of stomach	UBERON:0001161	64.58	gold quality
skin of leg	UBERON:0001511	64.10	gold quality
anterior cingulate cortex	UBERON:0009835	62.24	gold quality
skin of abdomen	UBERON:0001416	61.91	gold quality
thyroid gland	UBERON:0002046	59.81	gold quality
small intestine Peyer’s patch	UBERON:0003454	59.71	gold quality
upper lobe of left lung	UBERON:0008952	59.46	gold quality
left lobe of thyroid gland	UBERON:0001120	58.83	gold quality
Ammon’s horn	UBERON:0001954	55.45	gold quality
right testis	UBERON:0004534	45.77	gold quality
testis	UBERON:0000473	43.28	gold quality
left testis	UBERON:0004533	42.18	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.08

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.