MIR431

Summary

MIR431 (microRNA 431, HGNC:32027) is a microRNA gene on chromosome 14q32.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 574038 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32027
Approved symbol	MIR431
Name	microRNA 431
Location	14q32.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-431
Ensembl gene	ENSG00000208001
Ensembl biotype	miRNA
OMIM	611708
Entrez	574038
RNAcentral	URS000067427D — miRNA, 114 nt, 19 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385266

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385266 — 1 exons

Exon	Start	End
ENSE00001500272	100881007	100881120

Expression profiles

Bgee: expression breadth broad, 12 present calls, max score 74.44.

Top tissues by expression

12 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
left adrenal gland cortex	UBERON:0035825	74.44	gold quality
body of stomach	UBERON:0001161	71.05	gold quality
pituitary gland	UBERON:0000007	69.24	gold quality
left adrenal gland	UBERON:0001234	66.31	gold quality
hypothalamus	UBERON:0001898	66.21	gold quality
subcutaneous adipose tissue	UBERON:0002190	63.98	gold quality
kidney	UBERON:0002113	63.21	gold quality
nucleus accumbens	UBERON:0001882	61.24	gold quality
amygdala	UBERON:0001876	59.11	gold quality
cerebellar hemisphere	UBERON:0002245	57.41	gold quality
anterior cingulate cortex	UBERON:0009835	54.55	gold quality
left testis	UBERON:0004533	44.81	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 34)

• Human IFN-beta-induced miR-431 expression may down-regulate IGF1R and IRS2 expression, and consequently inhibit cell proliferation by suppressing the MAPK pathway. (PMID:22293894)
• Expression of miR-154*, miR-376b, and miR-431* were suppressed in leukocytes from initial Grave disease patients. (PMID:22456620)
• MiR-431 was markedly down-regulated in the hepatocellular carcinoma samples compared with corresponding adjacent liver tissues. (PMID:25775917)
• Our results indicated that miR-431 could serve as a predictor for papillary thyroid carcinoma (PTC) patients with positive lymph node metastasis and a potential target of PTC treatment. (PMID:29945344)
• MiR-431 expression was reduced both in pancreatic cancer tissues and cell lines. Cell proliferative ability was effectively lessened after up-regulating miR-431. Elevated miR-431 significantly induced cell apoptosis and modulated cell cycle arrest. Meanwhile, CDK14 was a direct target gene of miR-431, and over-expression of miR-431 decreased the level of CDK14. (PMID:30058687)
• miR-431 inhibits adipogenic differentiation of human mesenchymal stem cells via targeting IRS2. (PMID:30165902)
• circSEMA4B serves as a miR-431 sponge to compete with SFRP1 or GSK-3beta for miR-431 binding, thus inhibiting IL-1beta-induced nucleus pulposus degenerative process in intervertebral disc degeneration. (PMID:30251693)
• Results found that the expression of miR-431 was increased in preeclampsia (PE) patients, whereas, the expression of ZEB1 was decreased. Furthermore, miR-431 was shown to inhibit the migration and invasion of trophoblastic cells by targeting ZEB1, which might give rise to the onset of PE. (PMID:30315928)
• these results indicated that FBXL19-AS1 was involved in progression and angiogenesis in lung cancer by targeting miR-431-5p/RAF1 axis, which provided a new insight into the therapeutic strategies of lung cancer. (PMID:30610161)
• The miR-431-FOXA1 axis could in part be responsible for the intensification of the inflammatory response in NEC tissues and contribute to the proinflammatory pathophysiology (PMID:30624964)
• miR-431 expression was significantly lower in lung cancer (LCa) tissue samples or cell lines compared to adjacent normal tissues or lung bronchial epithelial cell line, respectively. Overexpression of miR-431 significantly inhibited proliferation, invasion and migration of A549 cells. Downregulation of miR-431 accelerated cell growth and metastasis of H1650 cells. DDX5 was proved to be a direct target for miR-431 in LCa. (PMID:30720177)
• miR-431 under-expressed in patients with adrenocortical carcinoma (ACC) with progressive disease undergoing adjuvant therapy. Restoration of miR-431 in vitro decreased the half maximal inhibitory concentrations of doxorubicin with markedly increased apoptosis. Reversal of epithelial-mesenchymal transition underlies the action of miR-431, with ZEB1 is implicated as the molecular target of miR-431 in ACC. (PMID:30918109)
• miR-431-5p is critical for pulmonary surfactant expression. (PMID:30988675)
• MiR-431 is a prognostic marker and suppresses cell growth, migration and invasion by targeting NOTCH2 in melanoma. (PMID:31115015)
• Circ_0001742 promotes tongue squamous cell carcinoma progression via miR-431-5p/ATF3 axis. (PMID:31841185)
• Taken together, miR-431 silences DAB2IP to active Ras/Erk and promote metastasis of pancreatic neuroendocrine tumor (PNET). miR-431 may be targeted to manage metastatic PNETs. (PMID:31953039)
• A Novel Three-miRNA Signature Identified Using Bioinformatics Predicts Survival in Esophageal Carcinoma. (PMID:32104700)
• CircADAMTS6/miR-431-5p axis regulate interleukin-1beta induced chondrocyte apoptosis. (PMID:33305412)
• CircRNA_OTUD7A upregulates FOXP1 expression to facilitate the progression of diffuse large B-cell lymphoma via acting as a sponge of miR-431-5p. (PMID:33830472)
• MicroRNA-431-5p encapsulated in serum extracellular vesicles as a biomarker for proliferative diabetic retinopathy. (PMID:33838342)
• Identification of crucial noncoding RNAs and mRNAs in hypertrophic scars via RNA sequencing. (PMID:33932142)
• Circ_0001367 inhibits glioma proliferation, migration and invasion by sponging miR-431 and thus regulating NRXN3. (PMID:34035217)
• Silencing of the long noncoding RNA LINC01132 alleviates the oncogenicity of epithelial ovarian cancer by regulating the microRNA4315p/SOX9 axis. (PMID:34132375)
• FBXL19AS1 promotes the progression of nasopharyngeal carcinoma by acting as a competing endogenous RNA to sponge miR431 and upregulate PBOV1. (PMID:34278444)
• Circular RNA MAT2B promotes migration, invasion and epithelial-mesenchymal transition of non-small cell lung cancer cells by sponging miR-431. (PMID:34288814)
• Circ_0078710 promotes the development of liver cancer by upregulating TXNDC5 via miR-431-5p. (PMID:34606982)
• Circular RNA circCSPP1 promotes the occurrence and development of colon cancer by sponging miR-431 and regulating ROCK1 and ZEB1. (PMID:35101080)
• Transcriptomic and functional studies reveal miR-431-5p as a tumour suppressor in pancreatic ductal adenocarcinoma cells. (PMID:35182679)
• The role of human umbilical cord mesenchymal stem cells-derived exosomal microRNA-431-5p in survival and prognosis of colorectal cancer patients. (PMID:35460420)
• CircRTN1 acts as a miR-431-5p sponge to promote thyroid cancer progression by upregulating TGFA. (PMID:35804263)
• CircPTTG1IP knockdown suppresses rheumatoid arthritis progression by targeting miR-431-5p/FSTL1 axis. (PMID:35933079)
• Next generation sequencing reveals miR-431-3p/miR-1303 as immune-regulating microRNAs for active tuberculosis. (PMID:36057384)
• CircRNA circSTIL inhibits ferroptosis in colorectal cancer via miR-431/SLC7A11 axis. (PMID:36840697)
• [Overexpression of miR-431-5p impairs mitochondrial function and induces apoptosis in gastric cancer cells via the Bax/Bcl-2/caspase3 pathway]. (PMID:37202188)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Mir431	ENSMUSG00000070080
rattus_norvegicus	Mir431	ENSRNOG00000036498

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.