MIR4310

Summary

MIR4310 (microRNA 4310, HGNC:38383) is a microRNA gene on chromosome 15q15.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100423013 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38383
Approved symbol	MIR4310
Name	microRNA 4310
Location	15q15.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4310
Ensembl gene	ENSG00000264850
Ensembl biotype	miRNA
Entrez	100423013
RNAcentral	URS00007599FC — ncRNA, 57 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000582950

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000582950 — 1 exons

Exon	Start	End
ENSE00002711937	41866495	41866551

Expression profiles

Bgee: expression breadth broad, 26 present calls, max score 97.34.

Top tissues by expression

26 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	97.34	gold quality
Ammon’s horn	UBERON:0001954	73.94	gold quality
blood	UBERON:0000178	72.70	gold quality
fundus of stomach	UBERON:0001160	71.16	gold quality
body of stomach	UBERON:0001161	69.85	gold quality
amygdala	UBERON:0001876	69.48	gold quality
anterior cingulate cortex	UBERON:0009835	68.15	gold quality
tibial artery	UBERON:0007610	67.68	gold quality
skin of abdomen	UBERON:0001416	67.62	gold quality
omental fat pad	UBERON:0010414	66.93	gold quality
urinary bladder	UBERON:0001255	66.60	gold quality
skin of leg	UBERON:0001511	66.18	gold quality
right frontal lobe	UBERON:0002810	66.13	gold quality
tibial nerve	UBERON:0001323	66.09	gold quality
esophagus mucosa	UBERON:0002469	65.47	gold quality
cerebellar hemisphere	UBERON:0002245	65.32	gold quality
thyroid gland	UBERON:0002046	65.09	gold quality
vagina	UBERON:0000996	65.02	gold quality
prostate gland	UBERON:0002367	63.42	gold quality
right hemisphere of cerebellum	UBERON:0014890	63.41	gold quality
subcutaneous adipose tissue	UBERON:0002190	62.65	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	62.49	gold quality
endometrium	UBERON:0001295	60.24	gold quality
testis	UBERON:0000473	48.49	gold quality
left testis	UBERON:0004533	48.27	gold quality
right testis	UBERON:0004534	41.88	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.16

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• knockdown of CASC15 significantly inhibited the proliferation, migration and invasion of colon cancer cells in vitro and in vivo. Following mechanistic experiments, CASC15 was observed to act as a sponge to suppress microRNA (miR)4310 that targeted LGR5. (PMID:29956772)
• Differentially expressed miR-4310 functions as a tumor suppressor in colorectal cancer. (PMID:37545284)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.