MIR4311

Summary

MIR4311 (microRNA 4311, HGNC:38207) is a microRNA gene on chromosome 15q22.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422905 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38207
Approved symbol	MIR4311
Name	microRNA 4311
Location	15q22.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4311
Ensembl gene	ENSG00000263512
Ensembl biotype	miRNA
Entrez	100422905
RNAcentral	URS000075B632 — miRNA, 100 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000580794

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000580794 — 1 exons

Exon	Start	End
ENSE00002689948	66040233	66040332

Expression profiles

Bgee: expression breadth broad, 44 present calls, max score 76.70.

Top tissues by expression

44 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow	UBERON:0002371	76.70	gold quality
lung	UBERON:0002048	74.74	gold quality
corpus callosum	UBERON:0002336	74.26	gold quality
adrenal tissue	UBERON:0018303	71.36	gold quality
monocyte	CL:0000576	71.35	gold quality
right frontal lobe	UBERON:0002810	70.39	gold quality
gastrocnemius	UBERON:0001388	70.23	gold quality
blood	UBERON:0000178	69.36	gold quality
adult mammalian kidney	UBERON:0000082	69.16	gold quality
ascending aorta	UBERON:0001496	69.15	gold quality
amygdala	UBERON:0001876	69.00	gold quality
kidney	UBERON:0002113	69.00	gold quality
esophagus mucosa	UBERON:0002469	67.68	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.68	gold quality
skin of abdomen	UBERON:0001416	67.05	gold quality
right hemisphere of cerebellum	UBERON:0014890	66.84	gold quality
zone of skin	UBERON:0000014	66.61	gold quality
nucleus accumbens	UBERON:0001882	66.44	gold quality
skin of leg	UBERON:0001511	66.29	gold quality
cerebellar hemisphere	UBERON:0002245	66.23	gold quality
upper lobe of left lung	UBERON:0008952	66.12	gold quality
Brodmann (1909) area 9	UBERON:0013540	66.08	gold quality
Ammon’s horn	UBERON:0001954	65.89	gold quality
hypothalamus	UBERON:0001898	65.88	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	65.86	gold quality
spleen	UBERON:0002106	65.56	gold quality
body of stomach	UBERON:0001161	64.94	gold quality
putamen	UBERON:0001874	64.86	gold quality
anterior cingulate cortex	UBERON:0009835	64.37	gold quality
substantia nigra	UBERON:0002038	64.18	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.17

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Long non-coding RNA LINC00472 inhibits oral squamous cell carcinoma via miR-4311/GNG7 axis. (PMID:35240924)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.