MIR4312

Summary

MIR4312 (microRNA 4312, HGNC:38376) is a microRNA gene on chromosome 15q23.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422971 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38376
Approved symbol	MIR4312
Name	microRNA 4312
Location	15q23
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4312
Ensembl gene	ENSG00000265195
Ensembl biotype	miRNA
Entrez	100422971
RNAcentral	URS000075B82D — miRNA, 76 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000579909

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000579909 — 1 exons

Exon	Start	End
ENSE00002699273	68801850	68801925

Expression profiles

Bgee: expression breadth broad, 99 present calls, max score 93.01.

Top tissues by expression

99 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow	UBERON:0002371	93.01	gold quality
adrenal tissue	UBERON:0018303	89.86	gold quality
monocyte	CL:0000576	87.34	gold quality
corpus callosum	UBERON:0002336	86.76	gold quality
calcaneal tendon	UBERON:0003701	84.00	gold quality
blood	UBERON:0000178	83.30	gold quality
kidney	UBERON:0002113	77.00	gold quality
placenta	UBERON:0001987	75.41	gold quality
lymph node	UBERON:0000029	75.36	gold quality
islet of Langerhans	UBERON:0000006	75.16	gold quality
descending thoracic aorta	UBERON:0002345	74.78	gold quality
smooth muscle tissue	UBERON:0001135	74.66	gold quality
muscle of leg	UBERON:0001383	74.54	gold quality
rectum	UBERON:0001052	74.31	gold quality
right lung	UBERON:0002167	74.06	gold quality
liver	UBERON:0002107	73.17	gold quality
gastrocnemius	UBERON:0001388	72.72	gold quality
adult mammalian kidney	UBERON:0000082	72.10	gold quality
right coronary artery	UBERON:0001625	71.78	gold quality
endometrium	UBERON:0001295	71.55	gold quality
adrenal gland	UBERON:0002369	71.49	gold quality
stomach	UBERON:0000945	71.42	gold quality
endocervix	UBERON:0000458	71.14	gold quality
heart	UBERON:0000948	71.14	gold quality
right lobe of liver	UBERON:0001114	71.05	gold quality
tonsil	UBERON:0002372	71.01	gold quality
left adrenal gland cortex	UBERON:0035825	70.78	gold quality
fundus of stomach	UBERON:0001160	70.65	gold quality
heart left ventricle	UBERON:0002084	70.32	gold quality
body of pancreas	UBERON:0001150	70.12	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.40

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.