MIR4313

Summary

MIR4313 (microRNA 4313, HGNC:38310) is a microRNA gene on chromosome 15q24.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100423035 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38310
Approved symbol	MIR4313
Name	microRNA 4313
Location	15q24.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4313
Ensembl gene	ENSG00000284385
Ensembl biotype	miRNA
Entrez	100423035
RNAcentral	URS000075BE25 — ncRNA, 101 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000580760

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000580760 — 1 exons

Exon	Start	End
ENSE00002701914	75762215	75762315

Expression profiles

Bgee: expression breadth broad, 36 present calls, max score 71.03.

Top tissues by expression

36 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
gastrocnemius	UBERON:0001388	71.03	gold quality
transverse colon	UBERON:0001157	70.10	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.67	gold quality
right lobe of liver	UBERON:0001114	68.55	gold quality
blood	UBERON:0000178	68.23	gold quality
heart left ventricle	UBERON:0002084	68.18	gold quality
ascending aorta	UBERON:0001496	68.02	gold quality
right coronary artery	UBERON:0001625	67.69	gold quality
tibial artery	UBERON:0007610	66.90	gold quality
right atrium auricular region	UBERON:0006631	66.87	gold quality
body of uterus	UBERON:0009853	66.82	gold quality
esophagus mucosa	UBERON:0002469	66.24	gold quality
muscle layer of sigmoid colon	UBERON:0035805	66.23	gold quality
esophagus	UBERON:0001043	66.08	gold quality
left ovary	UBERON:0002119	66.02	gold quality
lower esophagus muscularis layer	UBERON:0035833	65.32	gold quality
subcutaneous adipose tissue	UBERON:0002190	65.30	gold quality
skin of abdomen	UBERON:0001416	64.89	gold quality
skin of leg	UBERON:0001511	64.82	gold quality
omental fat pad	UBERON:0010414	64.76	gold quality
caudate nucleus	UBERON:0001873	62.94	gold quality
thoracic mammary gland	UBERON:0005200	62.53	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	60.19	gold quality
minor salivary gland	UBERON:0001830	59.99	gold quality
spleen	UBERON:0002106	59.65	gold quality
upper lobe of left lung	UBERON:0008952	59.65	gold quality
nucleus accumbens	UBERON:0001882	59.31	gold quality
tibial nerve	UBERON:0001323	58.48	gold quality
pituitary gland	UBERON:0000007	58.09	gold quality
left lobe of thyroid gland	UBERON:0001120	56.70	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.