MIR4314

Summary

MIR4314 (microRNA 4314, HGNC:38191) is a microRNA gene on chromosome 17p13.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422983 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38191
Approved symbol	MIR4314
Name	microRNA 4314
Location	17p13.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4314
Ensembl gene	ENSG00000264005
Ensembl biotype	miRNA
Entrez	100422983
RNAcentral	URS000075CFE3 — ncRNA, 92 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000583321

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000583321 — 1 exons

Exon	Start	End
ENSE00002730206	8088056	8088147

Expression profiles

Bgee: expression breadth broad, 47 present calls, max score 74.83.

Top tissues by expression

47 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
gastrocnemius	UBERON:0001388	74.83	gold quality
blood	UBERON:0000178	73.70	gold quality
islet of Langerhans	UBERON:0000006	72.61	gold quality
endometrium	UBERON:0001295	72.52	gold quality
adult mammalian kidney	UBERON:0000082	72.00	gold quality
body of pancreas	UBERON:0001150	70.77	gold quality
stomach	UBERON:0000945	70.32	gold quality
lower esophagus muscularis layer	UBERON:0035833	69.91	gold quality
body of stomach	UBERON:0001161	69.38	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	69.38	gold quality
right atrium auricular region	UBERON:0006631	69.07	gold quality
transverse colon	UBERON:0001157	69.06	gold quality
upper lobe of left lung	UBERON:0008952	68.03	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.88	gold quality
colon	UBERON:0001155	67.49	gold quality
tibial artery	UBERON:0007610	66.73	gold quality
esophagus mucosa	UBERON:0002469	66.61	gold quality
omental fat pad	UBERON:0010414	66.11	gold quality
body of uterus	UBERON:0009853	65.78	gold quality
left coronary artery	UBERON:0001626	65.51	gold quality
skin of leg	UBERON:0001511	65.44	gold quality
putamen	UBERON:0001874	65.30	gold quality
vagina	UBERON:0000996	65.10	gold quality
nucleus accumbens	UBERON:0001882	65.08	gold quality
skin of abdomen	UBERON:0001416	64.82	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	64.70	gold quality
minor salivary gland	UBERON:0001830	64.51	gold quality
lung	UBERON:0002048	64.50	gold quality
subcutaneous adipose tissue	UBERON:0002190	64.31	gold quality
thoracic mammary gland	UBERON:0005200	63.99	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.65

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.