MIR4316

Summary

MIR4316 (microRNA 4316, HGNC:38306) is a microRNA gene on chromosome 17q25.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422851 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38306
Approved symbol	MIR4316
Name	microRNA 4316
Location	17q25.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4316
Ensembl gene	ENSG00000264060
Ensembl biotype	miRNA
Entrez	100422851
RNAcentral	URS000075C32A — miRNA, 71 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000579394

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000579394 — 1 exons

Exon	Start	End
ENSE00002713779	77396984	77397054

Expression profiles

Bgee: expression breadth broad, 59 present calls, max score 84.57.

Top tissues by expression

59 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	84.57	gold quality
blood	UBERON:0000178	77.05	gold quality
monocyte	CL:0000576	74.85	gold quality
liver	UBERON:0002107	72.98	gold quality
heart left ventricle	UBERON:0002084	71.88	gold quality
heart	UBERON:0000948	70.92	gold quality
tibial artery	UBERON:0007610	70.78	gold quality
lung	UBERON:0002048	68.28	gold quality
right lobe of liver	UBERON:0001114	67.62	gold quality
skin of abdomen	UBERON:0001416	67.11	gold quality
body of stomach	UBERON:0001161	66.82	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	66.67	gold quality
fallopian tube	UBERON:0003889	66.60	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	66.55	gold quality
stomach	UBERON:0000945	66.47	gold quality
granulocyte	CL:0000094	66.19	gold quality
omental fat pad	UBERON:0010414	65.90	gold quality
transverse colon	UBERON:0001157	65.79	gold quality
right uterine tube	UBERON:0001302	65.76	gold quality
muscle layer of sigmoid colon	UBERON:0035805	65.60	gold quality
left adrenal gland	UBERON:0001234	65.44	gold quality
esophagus mucosa	UBERON:0002469	65.33	gold quality
Ammon’s horn	UBERON:0001954	65.24	gold quality
upper lobe of left lung	UBERON:0008952	65.24	gold quality
ectocervix	UBERON:0012249	65.13	gold quality
body of uterus	UBERON:0009853	65.11	gold quality
lower esophagus muscularis layer	UBERON:0035833	65.11	gold quality
vagina	UBERON:0000996	64.83	gold quality
colon	UBERON:0001155	64.82	gold quality
right ovary	UBERON:0002118	64.67	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.65

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• elevated expression of miR-506 and miR-4316 in peripheral blood were potential molecular markers for early colorectal cancer. (PMID:28405738)
• findings demonstrated a key role of circMYO9B/miR-4316/FOXP4 axis in regulating BC progression (PMID:29702064)
• long noncoding RNA CALML3-AS1 promotes tumorigenesis of bladder cancer via regulating ZBTB2 by suppression of microRNA-4316 (PMID:30177388)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.