MIR4317

Summary

MIR4317 (microRNA 4317, HGNC:38260) is a microRNA gene on chromosome 18p11.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422840 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38260
Approved symbol	MIR4317
Name	microRNA 4317
Location	18p11.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4317
Ensembl gene	ENSG00000283532
Ensembl biotype	miRNA
Entrez	100422840
RNAcentral	URS000075C718 — ncRNA, 65 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000637586

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000637586 — 1 exons

Exon	Start	End
ENSE00003800118	6374361	6374425

Expression profiles

Bgee: expression breadth broad, 54 present calls, max score 80.80.

Top tissues by expression

54 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	80.80	gold quality
calcaneal tendon	UBERON:0003701	80.58	gold quality
monocyte	CL:0000576	79.93	gold quality
blood	UBERON:0000178	78.56	gold quality
liver	UBERON:0002107	77.35	gold quality
corpus callosum	UBERON:0002336	74.81	gold quality
lung	UBERON:0002048	74.33	gold quality
stomach	UBERON:0000945	73.87	gold quality
adult mammalian kidney	UBERON:0000082	73.85	gold quality
heart	UBERON:0000948	73.24	gold quality
right atrium auricular region	UBERON:0006631	71.39	gold quality
endometrium	UBERON:0001295	69.61	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	68.11	gold quality
right lobe of liver	UBERON:0001114	67.95	gold quality
Brodmann (1909) area 9	UBERON:0013540	67.80	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.38	gold quality
hypothalamus	UBERON:0001898	67.18	gold quality
left ovary	UBERON:0002119	66.91	gold quality
intestine	UBERON:0000160	66.63	gold quality
skin of leg	UBERON:0001511	66.63	gold quality
muscle layer of sigmoid colon	UBERON:0035805	66.55	gold quality
substantia nigra	UBERON:0002038	66.43	gold quality
minor salivary gland	UBERON:0001830	66.42	gold quality
brain	UBERON:0000955	66.13	gold quality
left adrenal gland	UBERON:0001234	66.13	gold quality
transverse colon	UBERON:0001157	65.46	gold quality
amygdala	UBERON:0001876	65.29	gold quality
right ovary	UBERON:0002118	65.27	gold quality
omental fat pad	UBERON:0010414	65.21	gold quality
skin of abdomen	UBERON:0001416	64.88	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.25

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 5)

• Forced expression of miR-4317 suppressed gastric cancer cell proliferation and blocked S-G2/M transition. Bioinformatics and dual-luciferase reporter assays confirmed that ZNF322 is a direct target of miR-4317. (PMID:28880489)
• Our results indicate that miR-4317 can reduce Non-small cell lung cancer (NSCLC) cell growth and metastasis by targeting FGF9 and CCND2. These findings provide new evidence of miR-4317 as a potential non-invasive biomarker and therapeutic target for NSCLC. (PMID:30227870)
• Clinicopathological and prognostic significance of miR-4317 expression in gastric cancer patients. (PMID:31002131)
• MicroRNA-4317 predicts the prognosis of breast cancer and inhibits tumor cell proliferation, migration, and invasion. (PMID:32279128)
• MicroRNA-4317 suppresses the progression of hepatocellular carcinoma by targeting ZNF436-mediated PI3K/AKT signaling pathway. (PMID:34861581)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.