MIR4318

Summary

MIR4318 (microRNA 4318, HGNC:38333) is a microRNA gene on chromosome 18q12.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422857 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38333
Approved symbol	MIR4318
Name	microRNA 4318
Location	18q12.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4318
Ensembl gene	ENSG00000266530
Ensembl biotype	miRNA
Entrez	100422857
RNAcentral	URS000075E32C — miRNA, 81 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000580543

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000580543 — 1 exons

Exon	Start	End
ENSE00002697025	37657135	37657215

Expression profiles

Bgee: expression breadth broad, 16 present calls, max score 80.69.

Top tissues by expression

16 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
intestine	UBERON:0000160	80.69	gold quality
blood	UBERON:0000178	74.63	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.70	gold quality
tibial nerve	UBERON:0001323	64.02	gold quality
right frontal lobe	UBERON:0002810	62.23	gold quality
right hemisphere of cerebellum	UBERON:0014890	62.02	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	61.47	gold quality
cerebellar hemisphere	UBERON:0002245	61.08	gold quality
subcutaneous adipose tissue	UBERON:0002190	61.00	gold quality
caudate nucleus	UBERON:0001873	60.50	gold quality
lung	UBERON:0002048	58.96	gold quality
Brodmann (1909) area 9	UBERON:0013540	58.76	gold quality
left testis	UBERON:0004533	47.96	gold quality
stomach	UBERON:0000945	47.06	gold quality
corpus callosum	UBERON:0002336	44.39	silver quality
right testis	UBERON:0004534	40.76	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.33

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.