MIR4319

Summary

MIR4319 (microRNA 4319, HGNC:38212) is a microRNA gene on chromosome 18q12.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422829 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38212
Approved symbol	MIR4319
Name	microRNA 4319
Location	18q12.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4319
Ensembl gene	ENSG00000265957
Ensembl biotype	miRNA
Entrez	100422829
RNAcentral	URS000075A53A — ncRNA, 85 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000577285

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000577285 — 1 exons

Exon	Start	End
ENSE00002728169	44970082	44970166

Expression profiles

Bgee: expression breadth broad, 79 present calls, max score 80.12.

Top tissues by expression

79 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
kidney	UBERON:0002113	80.12	gold quality
blood	UBERON:0000178	79.68	gold quality
bone marrow	UBERON:0002371	78.83	gold quality
liver	UBERON:0002107	77.82	gold quality
calcaneal tendon	UBERON:0003701	76.36	gold quality
monocyte	CL:0000576	76.31	gold quality
muscle of leg	UBERON:0001383	75.73	gold quality
placenta	UBERON:0001987	75.72	gold quality
stomach	UBERON:0000945	75.49	gold quality
gastrocnemius	UBERON:0001388	74.90	gold quality
adult mammalian kidney	UBERON:0000082	74.77	gold quality
adrenal tissue	UBERON:0018303	73.76	gold quality
heart	UBERON:0000948	73.35	gold quality
corpus callosum	UBERON:0002336	73.10	gold quality
islet of Langerhans	UBERON:0000006	72.62	gold quality
thoracic mammary gland	UBERON:0005200	71.16	gold quality
right atrium auricular region	UBERON:0006631	71.14	gold quality
prefrontal cortex	UBERON:0000451	70.40	gold quality
heart left ventricle	UBERON:0002084	69.78	gold quality
intestine	UBERON:0000160	68.92	gold quality
body of pancreas	UBERON:0001150	68.74	gold quality
colon	UBERON:0001155	68.74	gold quality
body of stomach	UBERON:0001161	68.62	gold quality
tibial artery	UBERON:0007610	68.30	gold quality
lung	UBERON:0002048	68.16	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.49	gold quality
thoracic aorta	UBERON:0001515	67.48	gold quality
left ovary	UBERON:0002119	67.20	gold quality
ascending aorta	UBERON:0001496	67.07	gold quality
transverse colon	UBERON:0001157	66.94	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.31

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 12)

• The growth and chemo-resistance of prostate cancer cells may be suppressed via re-expression of miR-4319 that inhibits Her-2 signaling. (PMID:29633185)
• MiR-4319 as a tumor suppressor gene in the maintenance of cancer stem cells stemness and confirmed that miR-4319 could inhibit the tumor initiation and metastasis of cancer stem cells mainly through downregulation of E2F2, which afforded the database to help understand the aggressive phenotype of triple-negative breast cancer. (PMID:30021199)
• Study demonstrates that miR-4319 is expressed at a low level in colorectal cancer (CRC) tissues, which predicts the poor clinical outcome of CRC. MiR-4319 regulates the proliferation, cell cycle, invasion and migration of CRC cells. Mechanically, miR-4319 is found to be transcriptionally regulated by PLZF, and acts as a tumour suppressor in CRC by targeting ABTB1. (PMID:31065369)
• MiR-4319 was proved to elicit tumor-suppressive role in tumorigenesis of NSCLC through hampering cell proliferation and migration as well as inducing apoptosis. (PMID:31096145)
• miR-4319 inhibited the development of thyroid cancer by modulating FUS-stabilized SMURF1. (PMID:31148243)
• GNAS-AS1/miR-4319/NECAB3 axis promotes tumor progression of non-small cell lung cancer by altering macrophage polarization. (PMID:31267263)
• miR-4319 Suppresses the Growth of Esophageal Squamous Cell Carcinoma Via Targeting NLRC5. (PMID:31746301)
• Long non-coding RNA LINC00426 contributes to doxorubicin resistance by sponging miR-4319 in osteosarcoma. (PMID:32620145)
• lncRNA DANCR Promotes Proliferation and Metastasis of Breast Cancer Cells Through Sponging miR-4319 and Upregulating VAPB. (PMID:32818383)
• Long non-coding RNA HOXA-AS3 facilitates the malignancy in colorectal cancer by miR-4319/SPNS2 axis. (PMID:34671931)
• MiR-4319 targets tuftelin 1 to reduce malignancy of cervical cancer cells. (PMID:38650156)
• CircATXN7 regulates the proliferation and invasion of esophageal cancer cells through miR-4319/NLRC5. (PMID:39121974)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.