MIR432

Summary

MIR432 (microRNA 432, HGNC:32083) is a microRNA gene on chromosome 14q32.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 574451 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32083
Approved symbol	MIR432
Name	microRNA 432
Location	14q32.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-432
Ensembl gene	ENSG00000272458
Ensembl biotype	miRNA
Entrez	574451
RNAcentral	URS00006284D8 — miRNA, 94 nt, 6 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000606207

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000606207 — 1 exons

Exon	Start	End
ENSE00003698181	100884483	100884576

Expression profiles

Bgee: expression breadth tissue_specific, 5 present calls, max score 74.36.

Top tissues by expression

5 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
stomach	UBERON:0000945	74.36	gold quality
body of pancreas	UBERON:0001150	69.56	gold quality
multicellular organism	UBERON:0000468	68.46	gold quality
prefrontal cortex	UBERON:0000451	64.84	gold quality
pituitary gland	UBERON:0000007	59.83	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 36)

• Cancer cells silence ADAR1 by overexpressing miR-17 and miR-432, which both directly target the ADAR1 transcript. (PMID:23728176)
• MiR-432 regulates neuronal differentiation of human neuroblastoma cells and significantly represses NESTIN and MECP2 expression. (PMID:24657437)
• To evaluate the association of miR-499 rs3746444 and miR-423 rs6505162 with hepatocellular carcinoma (HCC), we performed a large-scale case-control study of 984 patients with HCC and 991 cancer-free controls (PMID:24854593)
• Human miR432 regulate the replication of coxsackievirus A16 in rhabdomyosarcoma cells. (PMID:25272817)
• report uncovers a novel function of HSF1 and indicates involvement of miRNAs in HSF1-mediated protection of cellular proteome (PMID:25280995)
• Results demonstrated that miR-432 functions as a tumor-suppressive miRNA by suppressing Wnt/beta-catenin signaling activation. (PMID:25797263)
• Low expression level of miR432 is associated with lung adenocarcinoma. (PMID:26942465)
• Japanese Encephalitis Virus infection in human brain microglial cells downregulated the expression of miR-432, and upregulated SOCS5 levels. (PMID:27282499)
• The new results in our present research were that lncRNA625/miR-432 levels were consistently reduced in the prostate cancer tissues compared with the healthy control. (PMID:28678327)
• Results show that miR-432-3p was overexpressed in primary esophageal squamous cell carcinoma (ESCC) cells and that miR-432-3p can downregulate KEAP1 by directly binding to its coding region. Also, high expression of miR-432-3p was shown to contribute to decrease the sensitivity of ESCC cells to chemotherapy drugs probably due to the increase in NRF2 protein. (PMID:28760781)
• Mechanistic investigations suggested that hsa_circ_0008039 served as a competing endogenous RNA (ceRNA) of miR-432-5p. Subsequently, E2F3 was identified as the functional target of miR-432-5p and overexpression of hsa_circ_0008039 elevated E2F3 expression in breast cancer. (PMID:29807010)
• Overexpression of circular RNA circ_001569 indicates poor prognosis in hepatocellular carcinoma and promotes cell growth and metastasis by sponging miR-411-5p and miR-432-5p. (PMID:30086881)
• Knockdown of ZFAS1 and miR-432-5p overexpression inhibited cell viability and enhanced the chemosensitivity of glioma cells to cisplatin. MiR-432-5p was a direct target of ZFAS1 in glioma cells. (PMID:31246330)
• Circular RNA cSMARCA5 regulates the progression of cervical cancer by acting as a microRNA432 sponge. (PMID:31922210)
• DNAH17-AS1 promotes pancreatic carcinoma by increasing PPME1 expression via inhibition of miR-432-5p. (PMID:32351291)
• CircSMARCA5 Facilitates the Progression of Prostate Cancer Through miR-432/PDCD10 Axis. (PMID:32407167)
• Down-regulation of circ-PTN suppresses cell proliferation, invasion and glycolysis in glioma by regulating miR-432-5p/RAB10 axis. (PMID:32629066)
• Effects of miR-432 and miR-548c-3p on the proliferation and invasion of osteosarcoma cells. (PMID:32862605)
• Long noncoding RNA ARRDC1-AS1 is activated by STAT1 and exerts oncogenic properties by sponging miR-432-5p/PRMT5 axis in glioma. (PMID:33220929)
• circ_100984-miR-432-3p axis regulated c-Jun/YBX-1/beta-catenin feedback loop promotes bladder cancer progression. (PMID:33314480)
• MicroRNA-432 Acts as a Prognostic Biomarker and an Inhibitor of Cell Proliferation, Migration, and Invasion in Breast Cancer. (PMID:33637448)
• Circular RNA circSOX4 promotes the proliferation, migration and apoptosis of hepatocellular carcinoma cells by down regulating microRNA-432 expression. (PMID:33660794)
• MicroRNA-432-5p regulates sprouting and intussusceptive angiogenesis in osteosarcoma microenvironment by targeting PDGFB. (PMID:33846539)
• CircRNA SEPT9 contributes to malignant behaviors of glioma cells via miR-432-5p-mediated regulation of LASP1. (PMID:33915163)
• Negative Correlation Between Circular RNA SMARC5 and MicroRNA 432, and Their Clinical Implications in Bladder Cancer Patients. (PMID:34482767)
• Tanshinone I restrains osteosarcoma progression by regulating circ_0000376/miR-432-5p/BCL2 axis. (PMID:34532813)
• DRAIC promotes growth of breast cancer by sponging miR-432-5p to upregulate SLBP. (PMID:34645975)
• Reduced expression of microRNA-432-5p by DNA methyltransferase 3B leads to development of colorectal cancer through upregulation of CCND2. (PMID:34801563)
• YY1 and eIF4A3 are mediators of the cell proliferation, migration and invasion in cholangiocarcinoma promoted by circ-ZNF609 by targeting miR-432-5p to regulate LRRC1. (PMID:34898474)
• Downregulation of Circ-CEP128 Enhances the Paclitaxel Sensitivity of Cervical Cancer Through Regulating miR-432-5p/MCL1. (PMID:35391656)
• Circular RNA circRNA-0039459 promotes the migration, invasion, and proliferation of liver cancer cells through the adsorption of miR-432. (PMID:35543347)
• miRNA-432 and SLC38A1 as Predictors of Hepatocellular Carcinoma Complicated with Alcoholic Steatohepatitis. (PMID:35663198)
• Circular RNA ciRS-7 promotes laryngeal squamous cell carcinoma development by inducing TGM3 hypermethylation via miR-432-5p/DNMT3B axis. (PMID:36356335)
• Hsa_circ_0001946 Ameliorates Mechanical Stress-induced Intervertebral Disk Degeneration Via Targeting miR-432-5p and SOX9. (PMID:37555796)
• Cancer associated fibroblast secreted miR-432-5p targets CHAC1 to inhibit ferroptosis and promote acquired chemoresistance in prostate cancer. (PMID:38769193)
• The novel circFKBP8/miR-432-5p/E2F7 cascade functions as a regulatory network in breast cancer. (PMID:39192374)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.