MIR4320

Summary

MIR4320 (microRNA 4320, HGNC:38369) is a microRNA gene on chromosome 18q21.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422865 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38369
Approved symbol	MIR4320
Name	microRNA 4320
Location	18q21.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4320
Ensembl gene	ENSG00000283343
Ensembl biotype	miRNA
Entrez	100422865
RNAcentral	URS000075D266 — ncRNA, 65 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000636981

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000636981 — 1 exons

Exon	Start	End
ENSE00003793098	50126499	50126563

Expression profiles

Bgee: expression breadth broad, 35 present calls, max score 85.13.

Top tissues by expression

35 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
kidney	UBERON:0002113	85.13	gold quality
adult mammalian kidney	UBERON:0000082	82.65	gold quality
lung	UBERON:0002048	81.05	gold quality
liver	UBERON:0002107	79.28	gold quality
stomach	UBERON:0000945	75.76	gold quality
body of pancreas	UBERON:0001150	75.76	gold quality
body of stomach	UBERON:0001161	74.33	gold quality
intestine	UBERON:0000160	71.16	gold quality
Ammon’s horn	UBERON:0001954	70.01	gold quality
colon	UBERON:0001155	69.50	gold quality
transverse colon	UBERON:0001157	69.45	gold quality
urinary bladder	UBERON:0001255	68.55	gold quality
esophagus mucosa	UBERON:0002469	67.05	gold quality
hypothalamus	UBERON:0001898	66.79	gold quality
skin of leg	UBERON:0001511	66.71	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.71	gold quality
multicellular organism	UBERON:0000468	66.25	gold quality
ascending aorta	UBERON:0001496	65.95	gold quality
skin of abdomen	UBERON:0001416	65.79	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	64.52	gold quality
putamen	UBERON:0001874	64.15	gold quality
vagina	UBERON:0000996	64.07	gold quality
small intestine Peyer’s patch	UBERON:0003454	63.39	gold quality
left lobe of thyroid gland	UBERON:0001120	62.86	gold quality
right frontal lobe	UBERON:0002810	62.46	gold quality
thyroid gland	UBERON:0002046	62.31	gold quality
minor salivary gland	UBERON:0001830	61.52	gold quality
thoracic mammary gland	UBERON:0005200	60.44	gold quality
right lobe of thyroid gland	UBERON:0001119	59.90	gold quality
prostate gland	UBERON:0002367	59.79	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.33

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.