MIR4321

Summary

MIR4321 (microRNA 4321, HGNC:38244) is a microRNA gene on chromosome 19p13.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100423031 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product.

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38244
Approved symbol	MIR4321
Name	microRNA 4321
Location	19p13.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4321
Ensembl gene	ENSG00000284272
Ensembl biotype	miRNA
Entrez	100423031
RNAcentral	URS000075E6AC — miRNA, 80 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000592276

RefSeq mRNA: 0

Canonical transcript exons

ENST00000592276 — 1 exons

Exon	Start	End
ENSE00003468992	2250639	2250718

Expression profiles

Bgee: expression breadth broad, 34 present calls, max score 79.15.

Highest expression (Bgee): lymph node, blood, body of stomach, adult mammalian kidney, muscle of leg.

Top tissues by expression

34 tissues by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lymph node	UBERON:0000029	79.15	gold quality
blood	UBERON:0000178	72.65	gold quality
body of stomach	UBERON:0001161	69.19	gold quality
adult mammalian kidney	UBERON:0000082	66.86	gold quality
muscle of leg	UBERON:0001383	66.60	gold quality
gastrocnemius	UBERON:0001388	65.17	gold quality
tibial artery	UBERON:0007610	63.56	gold quality
hypothalamus	UBERON:0001898	62.50	gold quality
heart left ventricle	UBERON:0002084	61.58	gold quality
small intestine Peyer’s patch	UBERON:0003454	60.81	gold quality
skin of abdomen	UBERON:0001416	60.72	gold quality
ascending aorta	UBERON:0001496	59.80	gold quality
vagina	UBERON:0000996	58.63	gold quality
left adrenal gland cortex	UBERON:0035825	57.80	gold quality
muscle layer of sigmoid colon	UBERON:0035805	57.49	gold quality
thoracic aorta	UBERON:0001515	57.05	gold quality
omental fat pad	UBERON:0010414	56.85	gold quality
prostate gland	UBERON:0002367	56.82	gold quality
transverse colon	UBERON:0001157	56.35	gold quality
skin of leg	UBERON:0001511	54.95	gold quality
esophagus mucosa	UBERON:0002469	54.61	gold quality
right lobe of thyroid gland	UBERON:0001119	54.16	gold quality
body of pancreas	UBERON:0001150	54.14	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	53.75	gold quality
testis	UBERON:0000473	53.10	gold quality
brain	UBERON:0000955	52.35	gold quality
right atrium auricular region	UBERON:0006631	52.23	gold quality
lower esophagus muscularis layer	UBERON:0035833	51.97	gold quality
left lobe of thyroid gland	UBERON:0001120	51.94	gold quality
tibial nerve	UBERON:0001323	51.10	gold quality
subcutaneous adipose tissue	UBERON:0002190	51.06	gold quality
upper lobe of left lung	UBERON:0008952	49.98	gold quality
anterior cingulate cortex	UBERON:0009835	44.46	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	43.89	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Genomic neighbors (locus context)

Genes flanking this one on the chromosome (NCBI/Entrez gene neighborhood). Positional context only — some neighbors share regulatory elements (bidirectional promoters, antisense/overlapping transcripts), but chromosomal adjacency is not itself a functional relationship (see Interactions for that).

Symbol	Type	Entrez
MIR1227	ncRNA	100302283
DOT1L-AS1	ncRNA	124904611
AMH	protein-coding	268
PLEKHJ1	protein-coding	55111
SF3A2	protein-coding	8175
DOT1L	protein-coding	84444
JSRP1	protein-coding	126306
PEAK3	protein-coding	374872
OAZ1	protein-coding	4946
MIR6789	ncRNA	102466736
LINGO3	protein-coding	645191
AP3D1	protein-coding	8943

Protein

Non-coding RNA — no protein product.

Function

Gene-set membership (MSigDB)

This non-coding RNA is a member of 1 curated MSigDB gene set — regulatory-target and signature collections that include it (it has no protein-based pathway / GO / interaction data).

chr19p13

ncRNA interactions

Experimentally supported non-coding-RNA interaction partners (NPInter).

showing 1 of 89 interaction partners:

Partner	Partner type	Level	Source
hsa-miR-4321	miRNA	RNA-RNA	miRanda with Ago CLIP data GSE102319

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No curated drug or pharmacology associations for this gene.