MIR4322

Summary

MIR4322 (microRNA 4322, HGNC:38261) is a microRNA gene on chromosome 19p13.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422925 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38261
Approved symbol	MIR4322
Name	microRNA 4322
Location	19p13.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4322
Ensembl gene	ENSG00000264266
Ensembl biotype	miRNA
Entrez	100422925
RNAcentral	URS000075ED2F — miRNA, 73 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000585009

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000585009 — 1 exons

Exon	Start	End
ENSE00002693717	10230413	10230485

Expression profiles

Bgee: expression breadth broad, 89 present calls, max score 83.41.

Top tissues by expression

89 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
vermiform appendix	UBERON:0001154	83.41	gold quality
placenta	UBERON:0001987	78.88	gold quality
fundus of stomach	UBERON:0001160	78.09	gold quality
muscle of leg	UBERON:0001383	75.53	gold quality
endometrium	UBERON:0001295	75.41	gold quality
blood	UBERON:0000178	74.97	gold quality
body of uterus	UBERON:0009853	72.98	gold quality
kidney	UBERON:0002113	72.78	gold quality
heart left ventricle	UBERON:0002084	72.57	gold quality
ectocervix	UBERON:0012249	72.55	gold quality
gastrocnemius	UBERON:0001388	72.42	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	72.42	gold quality
myometrium	UBERON:0001296	71.73	gold quality
descending thoracic aorta	UBERON:0002345	71.21	gold quality
heart	UBERON:0000948	70.88	gold quality
right lung	UBERON:0002167	70.83	gold quality
right atrium auricular region	UBERON:0006631	70.68	gold quality
lung	UBERON:0002048	70.33	gold quality
stomach	UBERON:0000945	70.28	gold quality
substantia nigra	UBERON:0002038	70.21	gold quality
body of pancreas	UBERON:0001150	69.90	gold quality
monocyte	CL:0000576	69.71	gold quality
body of stomach	UBERON:0001161	69.69	gold quality
left uterine tube	UBERON:0001303	69.44	gold quality
upper lobe of left lung	UBERON:0008952	68.99	gold quality
metanephros cortex	UBERON:0010533	68.60	gold quality
tibial artery	UBERON:0007610	68.58	gold quality
popliteal artery	UBERON:0002250	68.57	gold quality
thoracic aorta	UBERON:0001515	68.34	gold quality
right ovary	UBERON:0002118	68.34	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.26

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.